1. PECAM-1 Is Down-Regulated in γδT Cells during Remission, but Up-Regulated in Relapse of Multiple Sclerosis.
- Author
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Zarobkiewicz, Michał K., Morawska, Izabela, Kowalska, Wioleta, Halczuk, Paweł, Roliński, Jacek, and Bojarska-Junak, Agnieszka A.
- Subjects
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MULTIPLE sclerosis , *T cells , *FLOW cytometry , *CD3 antigen - Abstract
Introduction. PECAM-1 and NKRP1A are both involved in the vascular transmigration of T lymphocytes. Vascular transmigration is a crucial process in multiple sclerosis pathogenesis. Methods and aim. The current paper presents an analysis of PECAM-1 and NKRP1A expression on γδ T cells. Expression of PECAM-1 and NKRP1A on subsets of γδ T cells was performed with flow cytometry. Results. Based on the flow cytometry data, PECAM1 was slightly differentially modulated on γδ T cells—it was up-regulated during relapse, but down-regulated during remission. Moreover, a significant downregulation of CD3 expression was noted on γδ T cells from MS patients, most notably during relapse. Conclusions. This may be a sign of the overall activation of γδ T cells in the course of multiple sclerosis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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