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In this paper, we propose an innovative approach to determine the approximate solution of the coupled time-fractional Keller-Segel (K-S) model. We use the fractional complex transform (FCT) to switch the model into its differential partner, and then, the homotopy perturbation method (HPM) is introduced to tackle its nonlinear elements using He's polynomials. This two-scale theory helps to define the physical meaning of the FCT for the solution of the K-S model. Some examples are illustrated to show that the proposed scheme presents the significant results. The considerable findings show that this strategy does not require any assumptions and also reduces the massive computations without imposing any constraints. This technique is also suitable in functional studies of fractal calculus due to its powerful and robust support for nonlinear problems. [ABSTRACT FROM AUTHOR]