1. IBD ACTIVITY AND HELICOBACTER PYLORI INFECTION.
- Author
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Gavrilescu, Otilia, Prelipcean, Cristina Cijevschi, Mihai, Catalina, Popa, Iolanda Valentina, Andronic, Andrei, Betisor, Elena, Jucan, Alina Ecaterina, and Dranga, Mihaela
- Subjects
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HELICOBACTER pylori infections , *CROHN'S disease , *INFLAMMATORY bowel diseases , *HELICOBACTER pylori , *ULCERATIVE colitis , *ANTIGEN analysis - Abstract
Introduction. There are an inverse association between Helicobacter Pylori (H. pylori) infection and prevalence of IBD [5, 10,11,12]. Also studies have reported an inverse association between H. pylori prevalence and disease severity of IBD [13]. H. pylori is one of the environmental infections causing changes in gut microbiota and immune system dysregulation, which may affect IBD activity. The current study aimed to compare the clinical, laboratory, and histological severity of the newly diagnosed IBD with the presence or absence of H. pylori infection. Methods. This was a retrospective study that included 50 newly diagnosed inflammatory bowel disease patients (30 ulcerative colitis patients and 20 Crohn's disease patients). Diagnosis of IBD was based on both endoscopy/colonoscopy and biopsy. Also, for assesing Disease activity was quatified by CDAI for Crohn disease and UCDAI dor ulcerative colitis. Also, fecal calprotectine was evaluated. The presence of H. pylori was evaluated by the H. pylori stool antigen test (HpSA). Results: The overall positivity of H. pylori infection in patients with IBD was 19.2%. Patients with HpSA had a significantly lower fecal calprotectine (145.57 ± 28.12 vs. 320.57 ± 67.54 (μg/mg); P= 0.02), Mayo score (4.12 ± 1.09 vs. 8.01 ± 1.23; P < 0.001) and CDAI score (112 ± 67 vs. 198 ± 89; P < 0.001) compared to those with negative HpSA. Conclusion. We reported a significantly lower H. pylori infection rate in IBD patients. H. pylori-positive IBD patients have a milder disease with less activity compared to H. pylori-negative IBD patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023