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Due to the increasing amount of new information that is emerging about COVID-19, traditional and web-based information sources are commonly used to spread and seek information. This study compared differences in information seeking, trust of information sources, and use of protective behaviors (e.g., mask wearing) among individuals in the US and China during the COVID-19 pandemic. A total of 722 valid responses in the US and 493 valid responses in China were collected via online surveys in May 2020. Pearson's Chi-square tests, independent samples t-tests, and multiple linear regressions were used to conduct the analyses. Results showed that US respondents accessed significantly fewer COVID-19 information sources, rated significantly lower levels of trust in these sources, and reported significantly lower levels of protective behaviors than the Chinese respondents. In both countries, trust in newspapers, radio/community broadcasting, and news portals were significantly positively correlated with protective behaviors. While trust of TV was significant in both populations, in China it was positively correlated, whereas in the US was negatively correlated, with protective behaviors. Findings from this study showed that coordinated and consistent messages from governmental officials, health authorities, and media platforms are important to promote and encourage protective behaviors. [ABSTRACT FROM AUTHOR]