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The research of biomedical data is crucial for disease diagnosis, health management, and medicine development. However, biomedical data are usually characterized by high dimensionality and class imbalance, which increase computational cost and affect the classification performance of minority class, making accurate classification difficult. In this paper, we propose a biomedical data classification method based on feature selection and data resampling. First, use the minimal-redundancy maximal-relevance (mRMR) method to select biomedical data features, reduce the feature dimension, reduce the computational cost, and improve the generalization ability; then, a new SMOTE oversampling method (Spectral-SMOTE) is proposed, which solves the noise sensitivity problem of SMOTE by an improved spectral clustering method; finally, the marine predators algorithm is improved using piecewise linear chaotic maps and random opposition-based learning strategy to improve the algorithm's optimization seeking ability and convergence speed, and the key parameters of the spectral-SMOTE are optimized using the improved marine predators algorithm, which effectively improves the performance of the over-sampling approach. In this paper, five real biomedical datasets are selected to test and evaluate the proposed method using four classifiers, and three evaluation metrics are used to compare with seven data resampling methods. The experimental results show that the method effectively improves the classification performance of biomedical data. Statistical test results also show that the proposed PRMPA-Spectral-SMOTE method outperforms other data resampling methods. [ABSTRACT FROM AUTHOR]