1. Waiting time distributions for clusters of receptors
- Author
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Higgins, Erin R., Schmidle, Heiko, and Falcke, Martin
- Subjects
- *
DISTRIBUTION (Probability theory) , *INOSITOL , *ENDOPLASMIC reticulum , *ION channels , *CYTOSOL , *CELL receptors , *PHOSPHATES - Abstract
Abstract: Inositol 1,4,5-trisphosphate receptor channels control release of from the endoplasmic reticulum into the cytosol of a cell. The binding of both 1,4,5-trisphosphate and activating is required for the channel to open. At high concentrations, s are inhibited. s are composed of four identical subunits and form in clusters. Many models have been proposed to describe how the binding of and to subunits results in the opening and closing of s. Here we compare the opening and closing probability distributions for clusters of s, resulting from three different models. The distributions are calculated both analytically, using a method we have developed, and with simulations. We found significant differences in the behavior of the three models as the and concentrations are varied. [Copyright &y& Elsevier]
- Published
- 2009
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