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With the rapidly increasing number of patent applications in China, each applicant tends to accumulate the quantity of patent, but not the improvement of patent quality. Therefore, the State Intellectual Property Office (SIPO) has recently issued a package of notification, which aims to reverse the status quo. However, existing methods of regional patent evaluation still emphasize on quantity rather than quality indices, which leads to biased evaluation results. In this paper, we establish a comprehensive index system for regional patent evaluation. The indicators of the system consist of four dimensions, including quantity, quality, structure, and coordination. This aims to provide a path of high-quality development for regional patent work. Based on the patent data of each city in Sichuan Province in 2020, this paper validated the effectiveness of the comprehensive evaluation system and put forward countermeasures and suggestions. [ABSTRACT FROM AUTHOR]