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The article discusses papers which show that signals derived from basophils and eosinophils are directly involved in the induction of T helper 2 (TH2)-cell responses. It highlights the findings in "A mechanism for the initiation of allergen-induced T helper type 2 responses," by C.L. Sokol and colleagues, and "Eosinophil-derived neurotoxin acts as an alarm to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses," by D. Yang and colleagues.

The article focuses on research on immune responses, regulatory T cells and T-cell signaling. Papers discussed which were published in other periodicals include "Dendritic Cell Stimulation By Mycobacterial Hsp70 is Mediated Through CCR5," by R. A. Floto et al and "Alterations in CD46-Mediated Tr1 Regulatory T Cells in Patients With Multiple Sclerosis," by A. L. Astier et al.