1. Neonatal NMDA blockade alters the LTP, LTD and cognitive functions in male and female Wistar rats.
- Author
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Golitabari, Nastaran, Mohammadian, Forouzan, Salari, Ali-Akbar, and Amani, Mohammad
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LABORATORY rats , *NEURAL transmission , *LONG-term potentiation , *NEUROPLASTICITY , *METHYL aspartate receptors , *THETA rhythm - Abstract
There is compelling evidence that neonatal blockade of NMDA receptors by phencyclidine (PCP) is associated with cognitive impairment in adulthood but little is known about the effects of early life PCP treatment on synaptic function later in life. Here, we sought to determine whether early life exposure to PCP alters the electrophysiologic function of hippocampal CA1 neurons in adult rats. To this end, male and female Wistar rats received either saline or PCP (10 mg/kg) on postnatal days (PND) 7, 9, and 11, and then underwent separate behavioral and electrophysiology tests in adulthood. Neonatal PCP treatment did not alter basic synaptic transmission and had only a modest effect on frequency following (FF) capacity but significantly decreased the paired-pulse facilitation (PPF) in the Schaffer collateral (SC)–CA1 pathway. We found that PCP treatment significantly attenuated the long-term potentiation (LTP) and long-term depression (LTD) in CA1 neurons accompanied by pronounced alteration in complex response profile in adult rats. The electrophysiology data were comparable in male and female rats and reliably associated with impaired spatial reference and working memories in these animals. Overall, this study suggests that blockade of NMDA receptors during early life deteriorates the short-term and long-term synaptic plasticity and complex response profile of CA1 neurons in adulthood. • Neonatal blockade of NMDARs deteriorates the short-term synaptic plasticity of CA1 neurons in adulthood. • Postnatal NMDA blockade attenuates the LTP and LTD in hippocampal SC–CA1 pathway. • Early life treatment with PCP results in pronounced deficits in spatial reference and working memories in adult rats. • Neonatal PCP treatment reduces the BDNF levels in the hippocampus and prefrontal cortex of adult rats. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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