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Objective: To assess the diagnostic accuracy of amniotic fluid Delta OD 450 values in the second and third trimesters of D-alloimmunized pregnancies.Methods: We searched our database for singleton D-alloimmunized pregnancies with nonhydropic fetuses, where amniocentesis was performed within 4 days of first fetal blood sampling. Amniotic fluid Delta OD 450 values were plotted on an extrapolated Liley's chart. Sensitivity and specificity were calculated for two commonly used cutoff levels, Liley's zone 3 and the upper third of Liley's zone 2. Severe fetal anemia was defined as a hemoglobin concentration of more than 5 standard deviations below the normal mean for corresponding gestational age.Results: Seventy-nine pregnancies met our inclusion criteria. Overall accuracy of the extrapolated Liley's curve in predicting severe fetal anemia was 75% (95% confidence interval [CI] 64, 84) for zone 3 and 86% (95% CI 77, 93) when the upper third of zone 2 was included. Sensitivity of Delta OD 450 values in Liley's zone 3 or the upper third of Liley's zone 2 was 95% (95% CI 74, 100) before and 98% (95% CI 89, 100) after 27 weeks.Conclusion: Liley's extrapolated curve predicts severe fetal anemia with reasonable accuracy and high sensitivity. [ABSTRACT FROM AUTHOR]

The article examines the angioarchitecture of monochorionic placentas with or without twin anemia-polycythemia sequence. Results revealed that a paucity of anastomoses and the absence of arterioarterial anastomoses are determinants of monochorionic twin placentas with twin anemia-polycythemia sequence. Also, it was found that the anastomoses found in twin anemia-polycythemia sequence were mostly small arteriovenous anastomoses.

The article evaluates the usefulness of the obstetric history and the maternal serum Kell antibody titer in the management of pregnancies with Kell alloimmunization. Results emphasized the significance of the close monitoring of Kell-alloimmunized pregnancies with a Kell-positive fetus and titers greater than or equal to 1:2 rom 16 to 17 weeks of gestation onward, for the timely detection of all cases of severe fetal anemia.

The study evaluates the effectiveness of antepartum transabdominal amnioinfusion to facilitate external cephalic version after initial failure. The mean gestational age of the seven women who participated in the study was 37 weeks and their mean amniotic fluid index before infusion was nine centimeter. Amnioinfusion was found not to facilitate external cephalic version after an initial failed attempt.