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Objectives. To determine the prevalence of Trypanasoma cruzi antibodies among the population under 18 years of age in the state of Veracruz, Mexico, and to identify risk factors associated with housing conditions and vector presence and distribution. Methods. A cross-sectional, epidemiological study of the population under 18 years of age living in 10 of the 11 health districts of the state of Veracruz, Mexico, from 2000 to 2001. Presence of T. cruzi antibodies was determined by hemagglutination inhibition test (HAl) and enzyme-linked immunosorbent assays (ELISA) of serum samples spotted on filter paper, and confirmed by HAl, ELISA, and indirect immunofluorescence assay (IFA) on serum samples. A questionnaire was administered to determined housing conditions, and entomological indices for triatomines were calculated for both the intra- and peridomiciliary areas. The results were analyzed using bifactorial and multifactorial unconditional logistic regression. Results. Of the 150 individuals presenting an initial reaction, 14 were confirmed positive (5 by HAl, ELISA and IFA; 6 by HAl and ELISA, and 3 by ELISA and IFA), for a total prevalence rate of 0.91% (95% CI: 0.85–0.94). All of the confirmed-positive cases were from five of 14 health districts, with the Tuxpan district having the highest prevalence rate: 5.2% (95%CI: 1.2–9.0). Risk factors included having noticed cracks in the house walls and gaps in the roof. The only species of vector captured was Triotoma dimidiata. The entomologic indices for infestation, colonization, and natural infection were: 10.9%, 50.0%, and 9.0%, respectively. Conclusions. Active, vector-borne transmission of T. cruzi was confirmed in the state of Veracruz, Mexico, with an overall antibody seroprevalence rate of 0.19% among the population under 18 years of age. Seroprevalence rates among this segment of the population, which serves as a sentinel group, should be closely monitored to determine if more stringent methods of vector control and epidemiological surveillance are needed. [ABSTRACT FROM AUTHOR]