1. Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.
- Author
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Ruiz-Perez, Begonia, Chung, Doo R., Sharpe, Arlene H., Yagita, Hideo, Kalka-Moll, Wiltrud M., Sayegh, Mohamed H., Kasper, Dennis L., and Tzianabos, Arthur O.
- Subjects
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LYMPHOCYTES , *POLYSACCHARIDES , *BIOMOLECULES , *IMMUNOGLOBULINS , *IMMUNE response , *FIBROSIS - Abstract
Bacterial carbohydrates have long been considered T cell-independent antigens that primarily induce humoral immune responses. Recently, it has been demonstrated that bacterial capsules that possess a zwitterionic charge motif can activate CD4+ T cells after processing and presentation by antigen-presenting cells. Here we show that these zwitterionic polysaccharides can prevent I helper 1-mediated fibrosis by signaling for the release of IL-10 from CD4+ T cells in vivo. IL-10 production by these T cells and their ability to prevent fibrosis is controlled by the inducible costimulator (ICOS)- ICOS ligand pathway. These data demonstrate that the interaction of the zwitterionic polysaccharides with T cells results in modulation of surgical fibrosis in vivo and suggest a previously undescribed approach to "harnessing" I cell function to prevent inflammatory tissue disorders in humans. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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