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Coal is an important energy resource in the world, especially in China. Extensive coal exploitation seriously damaged the grassland and its fragile ecosystem. However, temporal and spatial impact laws of open-pit coal exploitation on Landscape Ecological Health (LEH) of semi-arid grasslands are still not clear. Therefore, the main objective of this paper is to study impact of Large-scale Open-pit Coal Base (LOCB) on the LEH of semi-arid grasslands from the perspectives of temporal and spatial. Taking Shengli LOCB of Xilinguole grassland in Inner Mongolia as an example, we demonstrate a conceptual model of LOCB impact on LEH of semi-arid grasslands, and establish a research system called landscape Index-pattern Evolution-Driving force-Spatial statistics (IEDS). A complete process integrated from investigation, monitoring, and evaluation to the analysis of impact laws was developed. Result indicated that coal mining causes gradual increase of landscape patches, landscape fragmentation, gradual decline of landscape connectivity, complexity and irregularity of landscape shape, enhancement of landscape heterogeneity and complexity, gradual decline of landscape stability, gradual decrease of grassland landscape and annual increase of unhealthy grassland landscape. The LEH of grassland basically belongs to the state of slight deterioration. In the past 15 years, the spatial and temporal distribution characteristics of LEH in the study area are similar. This study provides scientific reference for ecological disturbance research, environmental protection, landscape planning, restoration and renovation of ecological environment in mining areas. At the same time, future research should integrate geological, hydrological, soil, vegetation, microorganisms, animals, climate, and other perspectives to study the impact of mining on landscape ecology deeply. [ABSTRACT FROM AUTHOR]