Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature 498:376-379, 2013). They have raised several hypothetical points that we further clarify here. [ABSTRACT FROM AUTHOR]
He, X., Liang, H., Zhao, Y., Peng, H., Liu, D., and Shao, Y.
Subjects
*HIV infections, *T cells
Abstract
An abstract of the conference paper "Two independent functions of Vγ2Vδ2 T cells discriminated by CD16 during HIV-1 infection," by H. Liang and colleagues is presented.
Liu, J ., Zhan, W., Kim, C., Lee, E., Cao, J., Ziegler, B., Gregor, A., Yue, F., Huibner, S., Macparland, S., Clayton, K., Schwartz, J., Song, H., Bento, E., Kovacs, C., Kaul, R., and Ostrowski, M.
Subjects
*HIV infections, *T cells
Abstract
An abstract of the research paper "Regulatory B cells are induced in untreated HIV-1 infection and suppress HIV-1 specific T cell responses," by J. Liu and colleagues is presented.