1. The Origins of Nucleotides.
- Author
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Powner, Matthew W., Sutherland, John D., and Szostaka, Jack W.
- Subjects
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PYRIMIDINE nucleotides , *PHOTOCHEMISTRY , *GLYCOSYLATION , *PHOSPHORYLATION - Abstract
The origins of life represent one of the most fundamental chemical questions being addressed by modern science. One of the longstanding mysteries of this field is what series of chemical reactions could lead to the molecular biologists dream; a pool of homochiral nucleotides? Here we summarize those results we consider to be historically important and outline our recently published research aimed at understanding the chemoselective origins of the canonical ribonucleotides. 1 Introduction 1.1 Nucleotides: What's the Problem? 2 Synthesis of Activated Pyrimidines 2.1 Pyrimidine Elaboration by Cyanovinylation 2.2 Photochemical Epimerization and Cytidine to Uridine Conversion 2.3 Urea-Mediated Phosphoryl Transfer and Intramolecular Rearrangement 2.4 Pyrimidine Photosanitization 3 Chemoselective Purine Glycosylation 4 Future Scope for Investigation 5 Conclusion [ABSTRACT FROM AUTHOR]
- Published
- 2011
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