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In recent years, with the development of high-throughput chromosome conformation capture (Hi-C) technology and the reduction of high-throughput sequencing cost, the data volume of whole-genome interaction has increased rapidly, and the resolution of interaction maps keeps improving. Great progress has been made in the research of 3D structure modeling of chromosomes and genomes. Several methods have been proposed to construct chromosome structures from chromosome conformation capture data. Based on the Hi-C data, this paper analyzes the relevant literature of 3D structure reconstruction of chromosomes and summarizes the principle of 3DMax, which is a classical algorithm to construct the 3D structure of a chromosome. In this paper, a new gradient ascent optimization algorithm called XNadam is proposed, which is a variant of Nadam optimization method. When XNadam is applied to 3DMax algorithm, the performance of 3DMax algorithm can be improved, which can be used to predict the three-dimensional structure of a chromosome. [ABSTRACT FROM AUTHOR]