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Objective, To investigate the clinical efficacy and safety of procedural manipulation under anesthesia (MUA) for joint adhesion after trauma of knee operation. Methods, Twenty one patients with joint adhesion after trauma of knee operation (including 6 cases after reconstruction and/or repair of multiple ligament injury of knee joint, 9 cases after internal fixation of fracture around the knee joint, and 6 cases after operation of patellar dislocation) were treated with procedural MUA. The knee flexion angle was evaluated before, during and after procedural MUA (2, 12 and 24 weeks) with joint protractor. The pain degree was evaluated by visual analogue scale (VAS) within 2 weeks after procedural MUA. The possible complications were recorded during and after procedural MUA. Results, Before, during and after procedural MUA (2, 12 and 24 weeks), the average knee flexion angle was 73.8°, 119.3°, 101.7°, 122.5° and 127.4°. Compared with preoperative, the average knee flexion angle increased 53.6° after procedural MUA (24 weeks). VAS evaluation results showed that the VAS score of patients in active state was more than 4 points only 1-3 days after operation. No complications occurred during and after the operation. Conclusion. Procedural MUA is relatively safe and effective in the treatment of joint adhesion after trauma of knee operation. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy and mechanism of Bushen Daozhuo granules in the treatment of chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS). Methods According to the selection criteria, 160 patients with CP/CPPS were collected and randomly divided into the control group and Chinese Medicine group, 80 cases each group. The patients in the control group were treated with oral tamsulosin hydrochloride sustained-release capsules, 0.2 mg/time, once a day, and the patients in the Chinese Medicine group with Bushen Daozhuo granules, 200 ml/time, twice a day. The chronic prostatitis symptom score (CPSI) and efficacy of the two groups were counted before treatment and 4 weeks after treatment, and their cytokines (TNF-α, IL-1β, IL-10), hemorheology (HBV, MBV, LBV), and serum sex hormones (LH, FSH, T, E2) levels were also measured. Results A total of 152 patients completed the study, including 75 in the control group and 77 in the Chinese Medicine group. After 4 weeks of treatment, the urination score, quality of life score, with TNF-α, IL-1β, and IL-10 in the prostate fluid of the control group were significantly improved compared with those before treatment (P<0.05). The cure rate, significant rate and total effective rate of the Chinese Medicine group were significantly higher than those of the control group. The CPSI scores, cytokines in the prostate fluid, blood rheology indexes and sex hormones (LH, T, E2) were significantly improved compared with those before treatment (P<0.05), and the degree of improvement was better than that of the control group (P<0.05). Conclusion Bushen Daozhuo granules is effective in treating CP/CPPS, and its mechanism may be to improve the inflammatory state in the prostate by regulating systemic hormones and hemorheology. [ABSTRACT FROM AUTHOR]