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This paper describes the regeneration mechanism of electrochemical regeneration technology, and emphatically introduces the effects of current density, regeneration time, electrolyte, electrolyte mass concentration, pH value and regeneration position on GAC regeneration efficiency, and the reactor for electrochemical regeneration of GAC. Finally, the development trend of electrochemical regeneration method is discussed, and it is pointed out that optimizing mechanism, developing other technologies based on electricity, and exploring the combination of electrochemistry and other technologies are the future research focuses of electrochemical regeneration of granular activated carbon. [ABSTRACT FROM AUTHOR]

Background and purpose: The current treatment of ovarian cancer is surgery and adjuvant platinum-based chemotherapy. However, relapse and drug resistance are common. We have demonstrated the platelet-activating factor receptor (PAFR) is highly expressed in epithelial ovarian cancer, promoting ovarian cancer cell proliferation and invasion. The objective was to explore the effect of PAFR expression on cisplatin (CDDP) in ovarian cancer cells to provide novel theoretical basis for ovarian cancer therapy. Methods: The upregulation of PAFR in CDDP-treated ovarian cancer cells was observed using Western blot and real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR). The role of nuclear factor Kappa-B (NF-κB)/p65 and hypoxia inducible factor-1α (HIF-1α) in modulating PAFR expression was assessed using Western blot, siRNA and immunofluorescence. The effect of PAFR on CDDP sensitivity was observed using a pharmacological inhibitor and siRNA knockdown. Results: CDDP induced dose- and timedependent upregulation of PAFR in two ovarian cancer cell lines (P<0.01). The downregulation of PAFR by CDDP correlated with the inhibitions of NF-κB and HIF-1α which were accumulated by CDDP in the nucleus. Inhibition of PAFR expression by PAFR specific small molecule antagonist WEB2086 or RNA interference could significantly improve the sensitivity of ovarian cancer cells to CDDP. The cell proliferation ability decreased significantly (P<0.01), while the apoptotic rate increased significantly (P<0.01). Increased expression of PAFR activated downstream AKT and ERK pathways in CDDP-treated cells. Conclusion: CDDP induces upregulation of PAFR by accumulating NF-κB and HIF-1α in the nucleus. PAFR inhibition may modulate the CDDP sensitivity in ovarian cancer cells, which is a novel and promising therapeutic target for sensitizing ovarian cancer cells to CDDP. [ABSTRACT FROM AUTHOR]

Background and purpose: The current treatment of ovarian cancer is surgery and adjuvant platinum-based chemotherapy. However, relapse and drug resistance are common. We have demonstrated the platelet-activating factor receptor (PAFR) is highly expressed in epithelial ovarian cancer, promoting ovarian cancer cell proliferation and invasion. The objective was to explore the effect of PAFR expression on cisplatin (CDDP) in ovarian cancer cells to provide novel theoretical basis for ovarian cancer therapy. Methods: The upregulation of PAFR in CDDP-treated ovarian cancer cells was observed using Western blot and real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR). The role of nuclear factor Kappa-B (NF-κB)/p65 and hypoxia inducible factor-1α (HIF-1α) in modulating PAFR expression was assessed using Western blot, siRNA and immunofluorescence. The effect of PAFR on CDDP sensitivity was observed using a pharmacological inhibitor and siRNA knockdown. Results: CDDP induced dose- and time-dependent upregulation of PAFR in two ovarian cancer cell lines (P<0.01). The downregulation of PAFR by CDDP correlated with the inhibitions of NF-κB and HIF-1α which were accumulated by CDDP in the nucleus. Inhibition of PAFR expression by PAFR specific small molecule antagonist WEB2086 or RNA interference could significantly improve the sensitivity of ovarian cancer cells to CDDP The cell proliferation ability decreased significantly (P<0.01), while the apoptotic rate increased significantly (P<0.01). Increased expression of PAFR activated downstream AKT and ERK pathways in CDDP-treated cells. Conclusion: CDDP induces upregulation of PAFR by accumulating NF-κB and HIF-1α in the nucleus. PAFR inhibition may modulate the CDDP sensitivity in ovarian cancer cells, which is a novel and promising therapeutic target for sensitizing ovarian cancer cells to CDDP. [ABSTRACT FROM AUTHOR]

Algebra system is a structural model based on concept lattice, and it is a newly developing structural model which needs further enhancement and extension, so it need take more time to research and exploration. For the above missing point, firstly, this paper explained the N algebra system, W algebra system and algebra system in cognitive informatics. Secondly, it discussed comparative analysis among above three core contents of algebra system. Finally, it proved N algebra system belongs to W algebra system. The conclusions of this paper lay a solid foundation and support for further develop of algebra system. [ABSTRACT FROM AUTHOR]

Objective To explore the mediating role of medical staff's autonomous motivation in the association between job requirements and job performance and to provide countermeasures and suggestions for improving medical staff's job performance. Methods By the convenience sampling method, 901 medical staff from 6 hospitals in Hangzhou were surveyed with the job demand scale, the autonomous motivation scale, and the job performance scale. The structural equation model was used to analyze the direct and indirect effects of job demand and autonomous motivation on job performance. Results Finally, 813 valid questionnaires were collected, with an effective recovery rate of 90.2%. In terms of job performance, the married medical staff scored higher, while those without a professional title or with working time less than 5 years scored lower (P < 0.05). The job requirements had a direct impact on job performance (β = 0.30, P < 0.01), which was indirectly affected through autonomous motivation (β = 0.069, P < 0.01), and the indirect effect percentage was 18.70%. Conclusions Autonomous motivation had a positive mediating effect on the association between job demands and job performance. Hospital managers should pay more attention to the working feelings of medical staff and give targeted guidance to medical staff with different levels of motivation to improve their autonomous motivation and, furthermore, to improve their work performance. [ABSTRACT FROM AUTHOR]

Aiming at the Petrochemical Industries Co GB201 compressor unit, the shaft displacement and shaft vibration signal of the turbine side appeared mutation phenomenon, the grounding brush for steam turbine, the BENTLY 3500 grounding system and the static electricity causes were researched. The unit could not be stopped, only to analyse related factors which could lead to malfunction. Exclude factors could be excluded, the steam turbine grounding brush was inspected and replaced on-line, the BENTLY 3500 grounding system was inspected and the influence of rotor electric or magnetic was analysised. Finally, it was determined that the static electricity from the lube oil by high speed rotor and bearing extrusion friction, and the bearing house was too larger to the joint of the TSI probe in the bearing house, the joint was soaked in the lube oil which temperature is 50° for a long time, the insulation may become worse, the electrostatic was accumulated to the joint, resulted electric charge accumulation and mutation phenomenon.After the unit was overhaul, the bearing house was opend and inspected, the prode joints were isolated afresh, when the unit was running again it was back to normal. The results indicate that the signal mutation is because of the static electricity from the lube oil by high speed rotor and bearing extrusion friction and the insulation of the TSI probe's joint is failure. [ABSTRACT FROM AUTHOR]