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Objective To explore the mediating role of self-esteem in the relationship between childhood adverse experiences (ACEs) and depressive symptoms of junior high school students, and the regulatory effect of social support. Methods A total of 1 308 students from 3 junior middle schools in Xiangxi were selected by stratified random cluster sampling from February to April 2023. A questionnaire survey was conducted with the use of Childhood adverse experience questionnaire, Adolescent social support scale, PHQ-9 Depression symptom screening scale, and Rosenberg self-esteem scale. The data were analyzed by correlation analysis, intermediary analysis, and moderated intermediary model test. Results (1) ACEs positively predicted depressive symptoms of junior high school students (β=0.801, t=7.246, P<0.05), while self-esteem and social support negatively predicted depressive symptoms of junior high school students (β=-0.406, t=-14.276, P < 0.05; β =-0.027, t=-2.781, P < 0.05). (2) Self-esteem played a mediating role between ACEs and depressive symptoms (effect=0.468, P < 0.05), and the mediating effect accounted for 31.33% of the total effect. (3) Social support directly regulated the relationship between ACEs and depressive symptoms (β=-0.017, t=-3.043, P<0.01), and social support played a regulatory role in the latter half of the mediating pathway of "ACEs self-esteem and depressive symptoms" (β=-0.004, t=-2.887, P<0.01). Conclusion There is a mediating effect between ACEs and depressive symptoms of junior high school students, and self-esteem is the mediating variable of the relationship between them. Social support buffers the influence of ACEs on the risk of depressive symptoms of junior high school students and strengthens the relationship between self-esteem and depressive symptoms. Therefore, giving more care and social support to junior high school students with ACEs and improving their self-esteem will help prevent and reduce the occurrence of depressive symptoms. [ABSTRACT FROM AUTHOR]

To establish a rat cardiovascular thrombosis model and to observe the fibrinolytic properties of the marine bisindole alkaloid FGFC1 (Fungi Fibrinolytic Compound 1) in dissolving rat cardiovascular thrombus, a rat cardiovascular thrombosis model was established using fluorescein 5-isothiocyanate (FITC )-labeled fibrin induction method. Myocardial tissue morphology was imaged by low-field NMR, fluorescence scanning of frozen sections and hematoxylin-eosin staining (HE) of paraffin sections. Plasma fluorescence intensity was measured in the blank group, control group, u-PA positive control group and FGFC1 low, medium and high dose groups., and plasma fibrin degradation product (FDP), D-dimer (D-D) and plasminogen (Pig) were measured by ELISA. FITC-FIB was successfully labeled as FITC-α, FITC-β, FITC-γγ peptide chains by reduced SDS-PAGE, and the FITC-fibrin showed green fluorescence under fluorescence microscopy. Low-field NMR imaging showed increased density of cardiac tissue in the modeling group, and fluorescence scanning of frozen sections showed the presence of fluorescent material plaques in cardiac vessels, indicating the establishment of a cardiovascular thrombosis model, while HE staining of tissue sections showed abnormal myocardial fibers in the modeling group, activity levels were significantly lower than those of the blank group, and FDP levels and D-D levels were significantly higher than those of the blank group. FITC-fibrin induced the formation of cardiovascular thrombosis model in rats, and the marine bisindole alkaloid FGFC1 could reduce the Pig activity and promote the degradation of thrombus fibrin in rats. [ABSTRACT FROM AUTHOR]