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Abstract The sizing of a small-scale linear Fresnel reflector directly influences its primary cost as well as the annual energy output and, hence, its financial attractiveness. In addition, the area required for its installation is a critical parameter in most of the applications. This paper presents the analysis of the effects of the longitudinal movement on the performance of small-scale linear Fresnel reflectors. Our design, patented in year 2017, shows to be really innovative when compared to the existing designs shown in the literature. The three-movement option marks the novelty of the design. The effect of three parameters (i.e. energy absorbed by the absorber tube, primary cost, and reflector area ratio) is evaluated for two locations in Europe. Different configurations are analyzed and compared with the typical configuration of a large-scale linear Fresnel reflector. Numerical simulations were carried out using a MATLAB code to calculate the energy absorbed by the absorber tube, the primary cost, and the reflector area ratio. The comparison of the configurations provided insight into how latitude impacts on the results. It will be demonstrated that both the energy absorbed by the absorber tube and the primary cost increase with longitudinal movement, while the reflector area ratio decreases. Highlights • An analysis of the effects of the longitudinal movement on the performance of SSLFRs is presented. • Two locations in Europe are evaluated. • Both the energy absorbed and the primary cost increase with longitudinal movement. • The reflector area ratio decreases with longitudinal movement. [ABSTRACT FROM AUTHOR]

The Mediterranean basin is the richest biodiversity region in Europe and a global hotspot of biological diversity. In spite of that, anthropogenic climate change is one of the most serious concerns for nature conservation in this region. One of the climatic threats is represented by shifts of the Mediterranean climate and expansion of the arid climate. In this paper, we present an assessment of changes in the spatial range of the Mediterranean climate in Europe and the conversion into arid climate under different greenhouse gas forcings, namely RCP4.5 and RCP8.5. We used 11 simulations in two future 30-year periods of state-of-the-art regional climate models from EURO-CORDEX. Our results indicate that by the end of the century under RCP8.5 the present Mediterranean climate zone is projected to contract by 16%, i.e. an area (~ 157,000 km2) equivalent to half the size of Italy. This compares with the less severe scenario RCP4.5 that projected only a 3% reduction. In addition, the Mediterranean climate zone is projected to expand to other zones by an area equivalent to 24 and 50% of its present extent under RCP4.5 and RCP8.5, respectively. Our study indicates that expansion of the arid zone is almost always the cause for contraction of the Mediterranean zone. Under RCP8.5 the arid zone is projected to increase by more than twice its present extent, equivalent to three times the size of Greece. Results of this study are useful for identifying (1) priority zones for biodiversity conservation, i.e. stable Mediterranean climate zones, (2) zones requiring assisted adaptation, such as establishment of new protected areas, implementation of buffer zones around protected areas and creating ecological corridors connecting stable Mediterranean zones. [ABSTRACT FROM AUTHOR]

In this paper we characterize the seasonal and inter-annual variabilities of cloud fraction profiles in both observations and simulation since they are critical to better assess the impact of clouds on climate variability. The spaceborne lidar onboard CALIPSO, providing cloud vertical profiles since 2006, is used together with a 23-year WRF simulation at 20 km resolution. A lidar simulator helps to compare consistently model with observations. The bias in observations due to the satellite under-sampling is first estimated. Then we examine the vertical variability of both occurrence and properties of clouds. It results that observations indicate a similar occurrence of low and high clouds over continent, and more high than low clouds over the sea except in summer. The simulation shows an overestimate (underestimate) of high (low) clouds comparing to observations, especially in summer. However the seasonal variability of cloud vertical profiles is well captured by WRF. Concerning inter-annual variability, observations show that in winter, those of high clouds is twice the low clouds one, an order of magnitude that is is well simulated. In summer, the observed inter-annual variability is vertically more homogeneous while the model still simulates more variability for high clouds than for low clouds. The good behavior of the simulation in winter allows us to use the 23 years of simulation and 8 years of observations to estimate the time period required to characterize the natural variability of the cloud fraction profile in winter, i.e. the time period required to detect significant anomalies and trends. [ABSTRACT FROM AUTHOR]

Patients, physicians, and health care providers in Europe have more than 10 years of experience with biosimilars. However, there are still debates if switching between a biosimilar and its reference product influences the efficacy of the treatment. In this paper, we address this uncertainty by developing a formal statistical test that can be used for showing that switching has no negative impact on the efficacy of biosimilars. For that, we first introduce a linear mixed-effects model that is used for defining the null hypothesis (switching influences the efficacy) and the alternative hypothesis (switching has no influence on the efficacy). Using this as the foundation of our work, we propose several approaches for testing for changes in the efficacy of the treatment due to switching and discuss the properties of these tests in an extensive simulation study. It is shown that all these methods have advantages and disadvantages and the decision regarding which method is preferred depends on the expectation of a switching assessment. To demonstrate the applicability of the methods in practice, the approaches were applied to the data of the EGALITY study, which compares the reference product Enbrel® (Amgen) with the approved biosimilar Erelzi® (Sandoz). [ABSTRACT FROM AUTHOR]

In this paper, we present a simple theoretical extension from the Economic Geography literature to characterize the main features of pollution havens (lax environmental regulation, good market access to high-income countries and corruption opportunities). Using structural and reduced-form estimations, we find that pollution havens are not a “popular myth” for European firms, laxer environmental standards significantly explain the location choice of polluting affiliates. We analyze in depth the role of trade costs (using various bilateral and multilateral measures), a 1% increase in access to the European market from a pollution haven fosters relocation there by 0.1%. We also find that corruption lowers environmental standards, which strongly attract polluting firms: a 1% increase of corruption fuels relocation by 0.28%. We test the economic significance of these empirical findings via simulations. The protection of the European market (e.g., a carbon tax on imports) to stop relocations to pollution havens must be high (a decrease of the European market for Morocco and Tunisia equivalent to 13%) not to say prohibitive (31% for China). [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance This paper has two overarching aims: (1) presenting the results of studying the Albacete tariff of medicines of 1526 and (2) broadly analyzing the origin and influences of medicinal traditional knowledge in the region of Albacete, Spain. We use historical and modern literature that may have influenced this knowledge. Our primary goal was to determine the ingredients used in the pharmacy in the 16th century CE in Albacete through the analysis of the tariff, and our secondary goal was to investigate until when ingredients and uses present in pharmacy and herbals persisted in later periods. Methods The identity of medicines and ingredients was determined by analyzing contemporary pharmacopoeias and classical pharmaceutical references. We analyzed further 21 sources (manuscripts, herbals, and books of medicines, pharmacopoeias, pharmacy inventories, and modern ethnobotanical records) for the presence/absence of ingredients and complex formulations of the tariff. Using factorial and cluster analysis and Bayesian inference applied to evolution models (reversible-jump Markov chain Monte Carlo), we compared textual sources. Finally, we analyzed the medicinal uses of the top 10 species in terms of frequency of citation to assess the dependence of modern ethnobotanical records on Renaissance pharmacy and herbals, and, ultimately, on Dioscorides. Results In Albacete 1526, we determined 101 medicines (29 simple drugs and 72 compound medicines) comprising 187 ingredients (85% botanical, 7.5% mineral, and 7.5% zoological substances). All composed medicines appear standardized in the pharmacopoeias, notably in the pharmacopoeia of Florence from 1498. However, most were no longer in use by 1750 in the pharmacy, and were completely absent in popular herbal medicine in Albacete 1995 as well as in Alta Valle del Reno (Italy) in 2014. Among the ingredients present in different formulation are the flowers of Rosa gallica , honey ( Apis mellifera ), the roots of Nardostachys jatamansi , and Convolvulus scammonia , pistils of Crocus sativus , grapes and raisins ( Vitis vinifera ), rhizomes of Zingiber officinale , bark of Cinnamomum verum , leaves and fruits of Olea europaea , mastic generally of Pistacia lentiscus , and wood of Santalum album . The statistical analysis of sources produces four well-separated clusters (Renaissance Herbals and Pharmacopoeias, Ethnobotany and Folk Medicine, Old phytotherapy, and Modern phytotherapy including Naturopathy) confirming our a priori classification. The clade of Renaissance Herbals and Pharmacopoeias appears separated from the rest in 97% of bootstrapped trees. Bayesian inference produces a tree determined by an initial set of two well-distinct core groups of ingredients: 64, locally used in Mediterranean Europe during centuries; and 45, imported, used in pharmacy during centuries. Complexity reached its maximum in Albacete 1526 and contemporary pharmacopoeias, gradually decreasing over time. The analysis of medicinal uses of the top 10 ingredients showed low coincidence between Dioscorides and different Renaissance herbals or medical treatises and of all of them with ethnobotany in Albacete. Conclusions Regarding our question: is there something new under the sun? In some aspects, the answer is “No”. The contrast between expensive drugs, highly valued medicines, and unappreciated local wild medicinal plants persists since the Salerno's school of medicine. Old medicine in Mediterranean Europe, as reflected by Albacete 1526 tariff of medicines, involved strict formulations and preferences for certain ingredients despite other ingredients locally available but underappreciated. This confirms the fact that any system of medicine does not get to use all available resources. Ethnobiological records of materia medica, in rural areas of Albacete, describe systems with a high degree of stability and resilience, where the use of local resources, largely wild but also cultivated, is predominant in contrast with the weight of imported exotic products in pharmacy. [ABSTRACT FROM AUTHOR]

Reanalysis models are rapidly gaining popularity for simulating wind power output due to their convenience and global coverage. However, they should only be relied upon once thoroughly proven. This paper reports the first international validation of reanalysis for wind energy, testing NASA's MERRA and MERRA-2 in 23 European countries. Both reanalyses suffer significant spatial bias, overestimating wind output by 50% in northwest Europe and underestimating by 30% in the Mediterranean. We derive national correction factors, and show that after calibration national hourly output can be modelled with R 2 above 0.95. Our underlying data are made freely available to aid future research. We then assess Europe's wind resources with twenty-year simulations of the current and potential future fleets. Europe's current average capacity factor is 24.2%, with countries ranging from 19.5% (Germany) to 32.4% (Britain). Capacity factors are rising due to improving technology and locations; for example, Britain's wind fleet is now 23% more productive than in 2005. Based on the current planning pipeline, we estimate Europe's average capacity factor could increase by nearly a third to 31.3%. Countries with large stakes in the North Sea will see significant gains, with Britain's average capacity factor rising to 39.4% and Germany's to 29.1%. [ABSTRACT FROM AUTHOR]

Studying and understanding human brain is one of the main challenges of 21st century scientists. The Human Brain Project was conceived for addressing this challenge in an innovative way, enabling collaborations between 112 partners spread in 24 European countries. The project is funded by the European Commission and will last until 2023. This paper describes the ongoing activity at one of the Italian units focused on innovative brain simulation through high performance computing technologies. Simulations concern realistic models of neurons belonging to the cerebellar cortex. Due to the level of biological realism, the computational complexity of this model is high, requiring suitable technologies. In this work, simulations have been conducted on high-end Graphical Processing Units (GPUs) and Field Programmable Gate Arrays (FPGAs). The first technology is used during model tuning and validation phases, while the latter allows to achieve real time elaboration, aiming at a possible development of embedded implantable systems. Simulations performance evaluations are discussed in the result section. [ABSTRACT FROM AUTHOR]

The number of elderly patients requiring hospitalisation in Europe is rising. With a greater proportion of elderly people in the population comes a greater demand for health services and, in particular, hospital care. Thus, with a growing number of elderly patients requiring hospitalisation competing with non-elderly patients for a fixed (and in some cases, decreasing) number of hospital beds, this results in much longer waiting times for patients, often with a less satisfactory hospital experience. However, if a better understanding of the recurring nature of elderly patient movements between the community and hospital can be developed, then it may be possible for alternative provisions of care in the community to be put in place and thus prevent readmission to hospital. The research in this paper aims to model the multiple patient transitions between hospital and community by utilising a mixture of conditional Coxian phase-type distributions that incorporates Bayes' theorem. For the purpose of demonstration, the results of a simulation study are presented and the model is applied to hospital readmission data from the Lombardy region of Italy. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Today computational fluid dynamics (CFD) is widely used in industrial companies, research institutes and technical safety organizations to supplement the design and analysis of diverse technical components and large systems. Such numerical programs are applied to better understand complex fluid flow and heat transfer phenomena. In the last decades there is an increasing interest in the nuclear community to utilize such advanced programs for the evaluation of different nuclear reactor safety issues, where traditional analysis tools show deficiencies. Within the FP7 European project THINS (Thermal Hydraulics of Innovative Nuclear Systems), CFD and coupled 1D-3D thermal–hydraulic simulations are being carried out. These are dedicated to the analysis of the thermal–hydraulics of gas, liquid metal and supercritical water cooled reactors. Such concepts utilize innovative fluids, which have different properties from the ones used in the current nuclear reactors. In order to improve the thermal–hydraulic predictions of their behavior, CFD development, application and validation activities are performed within THINS. This overview paper highlights some of the CFD related work within the European project. [ABSTRACT FROM AUTHOR]

• The paper presents NeMo, a model for the simulation of district heating networks. • The thermal inertia of the heat carrier fluid is used to shift the thermal load. • The flow rate regulation allows to shave the peak load during two typical weeks. • Water velocity, heat load pattern and grid topology affect the flexibility figures. • NeMo is released as supplementary material of the article. The possibility of recovering waste and renewable heat in urban areas has made district heating networks one of the key infrastructures for decarbonising the heating sector in Europe. The ability to shift the heat production over time is an important asset to improve the competitiveness of both new and existing networks. To this purpose, the present study evaluates the flexibility potential provided by the water volume enclosed in the network pipelines using the district heating network of Verona (Italy) as a case study. Given the users heat demand in two representative weeks, computer simulations were carried out to calculate the network's thermal response to circulating flow rate variations. The latter were designed to cause an early or late shift in the daily peak thermal load. The local temperature drop at the users substations compared to the current situation was used as a relative discomfort indicator. The simulations were carried out using the model NeMo, which has been attached as supplementary material to this publication. The simulation results show that the network pre-charge strategy achieves significant benefits in terms of both peak shaving and load shifting with a limited impact on discomfort for the users. Furthermore, the paper shows that the available storage capacity of the network is significantly influenced by the duration of the flow adjustment, by the average velocity of the heat carrier fluid and by the daily heat demand pattern. Finally, it is shown that the energy flexibility of the network also depends on its topology. In this regard, the article provides preliminary indications on the number and position of the bypass pipes needed to implement the proposed flow rate variations. In conclusion, the article shows that the thermal inertia of the heat carrier fluid is an interesting source of flexibility for existing networks, and the results highlight its potential and limitations. [ABSTRACT FROM AUTHOR]

The suction bucket foundation is considered as an effective option for offshore wind turbines because of its advantages in rapid installation and recyclability. However, the depth of the suction bucket inserted into the seabed is shallower compared to the monopile. Earthquakes and liquefaction threaten the safety and stability of suction bucket foundations in the North Sea of Europe and the Chinese offshore where earthquakes are active and the seabed is prone to liquefaction. This paper investigated the behavior of the suction bucket foundation located in the liquefiable sand under earthquakes using an advanced liquefaction model. The FE-FD method with the cyclic mobility constitutive model for soil was used to carry out the nonlinear dynamic analyses. Responses of the excess pore water pressure ratio, acceleration, displacement, and rotation were studied under different earthquake magnitudes and sand density. The distribution of excess pore water pressure of the suction bucket foundation from the results show strong space-time characteristics. The failure mechanism of the suction bucket foundation after liquefaction was revealed. The numerical results indicate that offshore wind turbines will be subjected to permanent displacements and tilt to reach 40% of the safety threshold due to earthquakes and liquefaction. Thus, seismic load and liquefaction of the foundation must be considered in the design. • Suction bucket foundation response under earthquakes was investigated using an advanced liquefaction model. • The excess pore water pressure ratio, acceleration, displacement, and rotation were studied. • The failure mechanism of the suction bucket foundation after liquefaction was revealed. • Seismic load and liquefaction of foundation are important items in the design. [ABSTRACT FROM AUTHOR]

• Augmented maturity method using FEM-based numerical tests in addition to the usual laboratory and field experimental methodology. • Recommendations for an effective laboratory research program and a reliable temperature measurement system. • FEM analysis of compressive strength distribution in the concrete deck of extradosed bridge. • The complex system of concrete monitoring improves the confidence of decisions on prestressing tendons or formwork removal and provides economic benefit. The work is devoted to the implementation of a monitoring system for high performance concrete embedded in the span of an extradosed bridge deck using a modified maturity method augmented by numerical simulations conducted by the authors' FEM code. The paper presents all research stages of bridge construction and considers the conclusions drawn from the results of laboratory tests, field measurements, and numerical calculations. The monitored structure is the largest extradosed bridge in Europe in terms of the span's length. Due to the considerable size and duration of the investment, it was beneficial to use an alternative method for estimating the compressive strength of concrete based on the maturity function. The bridge sections were investigated in three stages: in summer, autumn, and early spring (in June, September, and March). The monitoring of in-place concrete provided information on the actual temperature of the concrete and its gradients. Based on recorded temperatures and proposed numerical procedures, the actual strength of the cast-in-place concrete and the optimal dates of prestressing were determined. This contributed to shortening the work cycle and speeding up the work schedule. [ABSTRACT FROM AUTHOR]

Lightweight roof and wall structural systems are widely used for cladding of steel portal frames. It is a well-known fact, that assembled systems of profiled sheeting and purlins show significant stiffness to in-plane loads, which action is referred to as stressed skin effect. This research aimed to investigate the influencing parameters of stressed skin effect in those nonstandard diaphragm constructions, in which seam fasteners are omitted. The focus of this paper is on the results of an experimental test programme, that investigated the stiffness of nonstandard, 3.00 × 3.00 m sized diaphragm configurations for in-plane static load. The experimental results are compared against analytical results derived from calculated shear flexibilities according to current ECCS formulae. Upon experimental test results, a verified and validated numerical model is developed, and the range of experimental tests is extended by numerical simulations. The conclusions of numerical analyses demonstrated, that the effect of purlin section height and thickness is not followed by current ECCS provisions. The intended purpose of the research is to develop the current ECCS stressed skin design formulae to incorporate nonstandard diaphragm constructions, which are commonly used in industrial practice in Europe. The innovative feature of formulae improvement is to comprise the effect of those parameters, which are influencing shear flexibility and are not addressed in the current ECCS design methodology. Upon experimental, analytical and numerical results a modification is presented to current formulae of shear flexibility, which gives a better approach in nonstandard cases. • Experimental panel test series was conducted in order to examine the stiffening effect of commonly installed diaphragm configurations. • The main objective of the research is to examine nonstandard diaphragm constructions, in which seam fasteners are omitted. • To date no international study was performed to examine the stiffening effect of nonstandard steel diaphragms. • Upon experimental results a FE model was developed and verified, and an extended parametric study was carried out. • Based on these results a proposal is made in order to amend current ECCS formulae to incorporate nonstandard diaphragms. [ABSTRACT FROM AUTHOR]