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With the continuous deepening of the application of educational OA, massive educational data has been produced. Hence, the application of teaching big data (TBD) has a certain theoretical basis, practical methods, and research methods in the field of education. How to fully play the leading role of education on TBD in professional education, guide and recommend students to carry out personalized learning, change the teaching mode, enrich the teaching evaluation, then further improve the quality of talent training is a current issue, which has yet to be solved. Based on the analysis and mining of big data, this paper uses the spectral clustering algorithm to construct the curriculum association classification model and realizes the clustering of core courses. Then, through the analysis of the academic achievements of previous professional core courses, we can master the current situation of students' learning, construct the model as the portrait of students' individual, curriculum, and professional characteristics through deep learning, so as to realize the precise referral of personalized learning courses, provide students with targeted academic guidance, and further dynamically adjust the teaching syllabus, including the teaching methods and teaching means. Vice versa, we can improve the core courses clustering to further feedback on the curriculum association classification model by analyzing the job position technical requirements. Experiments show that the proposed model using a spectrum clustering algorithm could be better provided strong technical support for the decision-making of precision education in colleges and universities. [ABSTRACT FROM AUTHOR]