1. Modelling the interaction of T-Cells, antigen presenting cells, and HIV-1 in vivo
- Author
-
Lou, Jie and Shao, Yiming
- Subjects
- *
T cells , *LYMPHOCYTES , *ANTIGENS , *IMMUNITY , *BIOLOGY - Abstract
Abstract: We develop and analyze a model for the interactions of T-cells, antigen presenting cells (APCs), and HIV-1. Our model consists of five components: APCs, resting helper T-cells, activated uninfected helper T-cells, activated and infected helper T-cells, and the free virus. We emphasize the impact of APCs during HIV infection and the cell-to-cell contact manner in the transference of HIV-1 in vivo. The existence and stability of the uninfected steady state and those of the infected steady states are discussed. The uniform persistence of the system is also obtained. As a novel approach, multiple exposures of HIV-1 are illustrated and discussed in the paper. Through numerical stimulations, we check the sensitivity of APCs and helper T-cells in impacting the infection outcome and obtain some relevant results. We also give the lowest infectioe dose for certain individuals. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF