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Background: Adherence to medication in chronic conditions may be influenced by interventions from pharmacists. This study aimed to assess the impact of guidance and reminders from pharmacists on adherence to medication for hypertension, dyslipidemia, and chronic venous circulation disorders (CVCD) in Greece.Methods: The prospective CONCORD study aimed to record and report on change in self-reported adherence to medication following pharmacist reminders amongst a cohort of adult patients, diagnosed with at least one or a combination of these health conditions. All study participants were regular patients of a network of pharmacies in Attica and southern Greece. Pharmacists were trained to provide adherence reminders over 4 months. Impact on self-reported adherence of the intervention was reported at baseline and again in month 4.Results: Of the 1146 participants, 48% were men and 60% were aged 55– 74 years. Among them, 23.7% were diagnosed with hypertension, 16.5% with dyslipidemia, 3% with CVCD, 42.5% with hypertension and dyslipidemia, 3.1% with hypertension and CVCD, 2.6% with dyslipidemia and CVCD, and 8.6% with dyslipidemia, hypertension, and CVCD. In month 4 vs month 0, patients were less likely to forget to take their prescribed medications (p< 0.001), to be careless about their medications during the last 30 days (p< 0.001), and to temporarily discontinue their medications without prior doctor's advice (p< 0.001). Patients with CVCD were more prone to lower self-reported adherence compared to patients who were not diagnosed with CVCD or a combination of conditions that included CVCD.Discussion: Reminders and advice from pharmacists resulted in higher adherence to medication amongst participants in month 4 versus month 0.Conclusion: Pharmacist-enabled interventions, including reminders and advice, following targeted training, may positively impact on patient medication adherence in chronic health conditions.Plain Language Summary: This study aimed to measure the impact of reminders and advice on adherence to medication provided by private pharmacists to patients with hypertension, dyslipidemia, and/or chronic venous circulation disorders (CVCD) in Greece. Patients were asked to self-report adherence to medication at months 0 and 4, following advice and reminders received from trained pharmacists. Self-reported adherence was significantly improved at month 4 vs month 0 across our sample. Our study showed that pharmacist-enabled interventions, following targeted training, can quickly and significantly improve adherence to medication in patients with chronic diseases in Greece. [ABSTRACT FROM AUTHOR]