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1. MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17.

Author

Wu, Yang, Huang, Aixue, Li, Tao, Su, Xueting, Ding, Hongmei, Li, Hui, Qin, Xingliang, Hou, Lubin, Zhao, Qiang, Ge, Xingfeng, Fang, Tao, Wang, Rong, Gao, Changqing, Li, Jie, and Shao, Ningsheng

Subjects
*MICRORNA, *ATHEROSCLEROSIS, *ENDOTHELIAL cells, *GENE expression, *CELL proliferation, *CELL migration, *UMBILICAL veins, *BIOMARKERS, *ANATOMY, *DIAGNOSIS, *PATIENTS
Abstract

Highlights: [•] ADAM17 is an important factor in inflammation-associated vascular diseases. [•] ADAM17 is a direct target gene of miR-152. [•] MiR-152 inhibits the proliferation and migration of HUVECs. [•] Serum miR-152 levels are much lower in atherosclerosis patients than in normal individuals. [•] MiR-152 could be used as a diagnostic biomarker or therapeutic target in atherosclerosis. [Copyright &y& Elsevier]

Published
2014
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