1. Oxidative stress and cardiac dysfunction in children with chronic renal failure on regular hemodialysis.
- Author
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Al-Biltagi, Mohammed, Tolba, Osama, ElHafez, Maher, Abo-Elezz, Ahmed, Kady, Eman, and Hazza, Sahar
- Subjects
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HEART ventricle diseases , *ACADEMIC medical centers , *ANALYSIS of variance , *BLOOD pressure measurement , *C-reactive protein , *CARDIOVASCULAR diseases risk factors , *STATISTICAL correlation , *ECHOCARDIOGRAPHY , *GLOMERULAR filtration rate , *GLUTATHIONE , *HEART ventricles , *HEMODIALYSIS , *HEMODIALYSIS patients , *PROBABILITY theory , *STATISTICS , *T-test (Statistics) , *DATA analysis , *OXIDATIVE stress , *CASE-control method , *EARLY diagnosis , *DATA analysis software , *DESCRIPTIVE statistics , *CHILDREN , *DIAGNOSIS ,CHRONIC kidney failure complications ,RESEARCH evaluation - Abstract
Objective: The objective of this study was to evaluate cardiac function in children with end-stage renal disease (ESRD) on regular hemodialysis using speckle tracking echocardiography (STE) and correlate results with plasma glutathione level as a marker of oxidative stress. Methods: The study involved 30 children with ESRD and 30 healthy controls. The plasma glutathione and C-reactive protein (CRP) levels were measured, and cardiac function was evaluated using conventional echocardiography and STE. Results: Plasma glutathione levels were significantly lower and CRP significantly higher in patients than in controls. Children with ESRD had significant systolic and diastolic cardiac dysfunctions detected by STE compared with controls. Conventional echocardiography failed to detect these dysfunctions. There was significant increase in left-ventricular relative wall thickness (LV-RWT) in patients, especially those with hypertension, compared with the control group. There was also significant impairment of LV and right-ventricular (RV) global longitudinal strain (GLS) and torsion; however, LV-GLS was significantly better in hypertensive than in normotensive patients. The degree of impairment in GLS and cardiac torsion negatively correlated with plasma glutathione levels. Conclusion: Significant oxidative stress was present in children with ESRD and was correlated with the degree of cardiac dysfunction detected early using the new cardiac imaging modality, STE. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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