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Lion’s Mane Mushroom ( Hericium erinaceum ) is a traditional edible mushroom widely used in culinary applications and as an herbal medicine in East Asian countries. In the present study, two new aromatic compounds, hericerin A ( 1 ) and isohericenone J ( 5 ), along with five known compounds, isoericerin ( 2 ), hericerin ( 3 ), N -De phenylethyl isohericerin ( 4 ), hericenone J ( 6 ), and 4-[3′,7′-dimethyl-2′,6′-octadienyl]-2-formyl-3-hydroxy-5-methyoxybenzylalcohol ( 7 ), were isolated from a methanol extract of the fruiting bodies of H. erinaceum . The chemical structures of the compounds were determined from mass spectra and 1D- and 2D NMR spectroscopy. The anticancer effects of the isolated compounds were examined in HL-60 human acute promyelocytic leukaemia cells. Hericerin A ( 1 ) and hericerin ( 3 ) significantly reduced cell proliferation with IC 50 values of 3.06 and 5.47 μM, respectively. These same compounds also induced apoptosis of HL-60 cells, accompanied by time-dependent down-regulation of p-AKT and c-myc levels. These data suggest that compounds 1 and 3 from H. erinaceum are suitable for use in potential cancer treatments. [ABSTRACT FROM AUTHOR]