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Background and purpose: Gallstone is one of the most common problems of hepatobiliary system. Laparoscopic cholecystectomy is a gold standard treatment for this problem. Carbon dioxide (CO2) insufflated in the abdomen for better exposure in laparoscopic cholecystectomy could increase the liver enzyme levels. The goal of this study was to assess the effect of different CO2 pressure (12-16 mm Hg) on liver enzymes in laparoscopic cholecystectomy compared with open cholecystectomy. Materials and methods: In this clinical trial 60 patients were randomly assigned into three groups. The first group had low pressure (12mm Hg) laparoscopic cholecystectomy. The second group had laparoscopic cholecystectomy with high pressure (16mm Hg) and the third group had an open cholecystectomy. To assess the liver enzyme levels we checked the AST, ALT, ALP, LDH, and Bil, before, 24h, and 72h after surgery. Data analysis was done in SPSS ver.15 using repeated measures ANOVA. Results: The changes in liver function tests were significantly different before and 24h after the surgery in first and second group, however, these changes reduced to primary level after 72h. In the group with open cholecystectomy significant changes were seen in AST and ALT levels before and 24h after the surgery which decreased to primary level after 72h. The level of LDH was significantly different before and 24h after the surgery in group one and two. Conclusion: Gas insufflation in to abdomen transiently changed the liver enzyme levels that reduced to primary level after 72h. [ABSTRACT FROM AUTHOR]

Background and purpose: Population aging and advancing longevity is one of the achievements of the present century. Life satisfaction is considered as a typical sign of a successful adaptation to changes in various life situations. It seems that self-efficacy and social support may be associated with life satisfaction. There are limited publications in this field, so this study was done to investigate the relationship between life satisfactions, self-efficacy and social support in communitydwelling elderly in Sari, north of Iran. Materials and methods: In this descriptive-analytic study 129 elderly who agreed to participate were randomly selected from 10 health centers in Sari. The samples who aged more than 60 years of old were included and exclusion criteria were having incurables disease such as cancer, dementia, and severe psychological diseases. The data was collected using demographic questionnaires, Ed Diener life satisfaction, social support and self-efficacy questionnaires. To analyze the data SPSS V. 16 was applied. Results: The mean age of the elderly and life satisfaction were 67.86 ± 7.49 and 20.64 ± 8.36, respectively. We observed a significant correlation between life satisfaction and demographic variables such as economic status (P=0.002) and home status (P=0.01). Total average of social support and selfefficacy were 25.08 ± 5.98, 24.35 ± 7.55, respectively. This study found a significant association between life satisfaction with social support (r=0.44, P=0.001) and self-efficacy (r=0.49, P=0.001). Conclusion: According to the results of this study, there is a direct relationship between life satisfaction, social support, and self-efficacy. Life satisfaction in elderly can be increased by strengthening the support, independence and dignity of older people, thereby improving their social support and self-efficacy conditions. [ABSTRACT FROM AUTHOR]