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Objectives/Context: The main objective of this paper is to present an explanation for the divergent development trajectories of two regions of the capitalist world-economy, Latin America and East Asia. Methodology: starting from the concepts of world-economy, world region, regional focus and long durée, it is intended to verify how the forms of integration of the two regions to the capitalist worldeconomy affected them in three essential dimensions for economic development: State, capital accumulation and technological capability, from the 16th century to the present. Conclusions: having autonomously developed the three dimensions analyzed to the point of equating to the West at least until the end of the 17th century, when it was incorporated into the capitalist world-economy in the first half of the19th century, East Asia was able to take advantage of this integration and advance in global hierarchies of wealth and power. On the other hand, Latin America, which as a geopolitical entity was born together with the capitalist world-economy in the 16th century, was at that moment at a relatively low level of development in these dimensions, which, together with colonialism, continued to restrict its development and maintaining the region in its historical position as a periphery of the capitalist world-economy. Originality: the originality of this research is to establish a historically grounded principle of variation to explain the divergence in recent development trajectories of Latin America and East Asia. [ABSTRACT FROM AUTHOR]