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Objective: The article explores the existing scenarios and premium dynamics in the Coffee Axis Administrative and Planning Region (RAP EC) and its departmental entities. Methodology: For this purpose, researchers started from the range-size principle and distanced themselves from approaches that associated urban primacy with dysfunctionality in the spatial system under analysis, conceiving it as a particular aspect of urban concentration characteristic of capitalist development. The municipality was adopted as the spatial unit of analysis, and the population variable recorded by DANE in the 1985, 1993, 2005, and 2018 censuses was taken as input. Results: Indicators of inequality in the spatial distribution of this population were estimated, and indicators of urban primacy and chronological intensity in the evolution of this primacy condition were calculated. The information obtained in this way served to demonstrate the presence of primacy conditions at the departmental level, but the absence of such circumstances at the regional level. Conclusions: These results allowed concluding that there is a polycentric organization of the system of cities in the RAP EC, which constitutes a development asset favoring territorial cohesion in the region. This organization is based on the articulation of the departmental capitals. [ABSTRACT FROM AUTHOR]