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1. Interacción del componente pertussis de células completas con los antígenos tetánico, Haemophilus influenzae tipo B y hepatitis B en ensayos de potencia para vacunas combinadas.

Author

Landys, Mario, Figueroa, Juan Miguel, Lara, Ana, and Perdomo, Vicente

Subjects
*WHOOPING cough, *ANTIGENS, *COMBINED vaccines, *TETANUS, *HAEMOPHILUS influenzae, *HEPATITIS B, *ANIMAL models in research
Abstract

Combined vaccines have a higher level of acceptance in the population because fewer immunisations are required for protection against infectious diseases. Nevertheless, new challenges have appeared due to the report of some interference among the antigens included in such vaccines. The aim of this paper was to evaluate whole-cell Pertussis (wP) interference in potency tests with other antigens like tetanus, Haemophilus influenzae type b (Hib) and hepatitis B. For that purpose, we evaluated combined vaccines and compared them with the respective monovalent vaccines. Likewise, we prepared experimental formulations with different antigen combinations to evaluate the extent and nature of the interference caused by wP. We obtained a significant increase of the tetanus and Hib biological activities when both antigens are combined with wP, although it depended on the animal model and the experimental design used. On the other hand, wP decreased both the in vivo and in vitro potency of HB in a non-significant way. [ABSTRACT FROM AUTHOR]

Published
2008