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In recent years, with the development of high-throughput chromosome conformation capture (Hi-C) technology and the reduction of high-throughput sequencing cost, the data volume of whole-genome interaction has increased rapidly, and the resolution of interaction maps keeps improving. Great progress has been made in the research of 3D structure modeling of chromosomes and genomes. Several methods have been proposed to construct chromosome structures from chromosome conformation capture data. Based on the Hi-C data, this paper analyzes the relevant literature of 3D structure reconstruction of chromosomes and summarizes the principle of 3DMax, which is a classical algorithm to construct the 3D structure of a chromosome. In this paper, a new gradient ascent optimization algorithm called XNadam is proposed, which is a variant of Nadam optimization method. When XNadam is applied to 3DMax algorithm, the performance of 3DMax algorithm can be improved, which can be used to predict the three-dimensional structure of a chromosome. [ABSTRACT FROM AUTHOR]

In order to better explore the correlation between the dominant frequency (DF) of different endocardial mapping signals of patients with atrial fibrillation，this paper presents an improved algorithm based on the traditional Botteron，s algorithm. The algorithm can effectively extract DFs when the ventricular amplitude is larger. Signals collected by coronary sinus (CS) catheters and pulmonary venous (PV) catheters in 20 cases of clinical atrial fibrillation ablation procedures were observed and analyzed by Botteron，s algorithm and the improved algorithm. Equal DFs were found in both CS and PV signals in most of the cases. In addition，it was observed that the DFs of the CS were not only from the currently measured PV. Finally，based on the results of the above observation，this paper proposes a hypothesis that the potential ablation target should not only have relatively higher DFs， but also have consistent DFs of the signal collected from the atrium，which may provide a reference for finding the potential ablation target. [ABSTRACT FROM AUTHOR]

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