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Temperature and humidity independent control (THIC) systems demonstrate promising energy-saving potential compared with the conventional air conditioning systems. One type of THIC systems is proposed to use dual cooling sources with different temperatures since they could be produced easily by traditional vapor compression refrigeration chillers. This paper investigates the applicable condition of the THIC system based on dual cooling sources (DCSTHIC system). It is found that the DCSTHIC system has limited conditions (such as scopes of the heat moisture ratio and the fresh air rate) when applied, otherwise the indoor air temperature and humidity can’t be fulfilled, and further available scope of the heat moisture ratio realized by the DCSTHIC system is disclosed for air conditioned spaces. The minimum realized heat moisture ratio depends on the temperature of low-temperature cooling sources ( t LCS ). A parametric study is also conducted to analyze effects on the energy efficiency of DCSTHIC systems. These parameters include the heat moisture ratio ( ε ) and temperatures of dual cooling sources. Results show that DCSTHIC systems show more significant energy-saving potential in the air conditioned spaces with higher ε . The system COP improvement ranges from 3.1% to 17.5% compared with conventional air conditioning systems when the heat moisture ratio changes from 8000 kJ/kg to 15,000 kJ/kg. This study helps to guide the design and optimization of DCSTHIC systems. [ABSTRACT FROM AUTHOR]