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In this paper, we propose support vector-based supervised learning algorithms, called multiclass support vector data description with weighted dynamic time warping kernel function (MSVDD-WDTWK) and multiclass support vector machines with weighted dynamic time warping kernel function (MSVM-WDTWK), which provides a flexible and robust kernel function for time series classification between non-aligned time series data resulting in improved accuracy. The proposed WDTW kernel function provides an optimal match between two time series data by not only allowing a non-linear mapping between two data sequences, but also considering relative significance depending on the phase difference between points on time series data. We validate the proposed approaches using extensive numerical experiments on a number of multiclass UCR time series data mining archive, and demonstrate that our proposed methods provide lower classification error rates compared with existing techniques. [ABSTRACT FROM AUTHOR]

Background: Clinical Trials (CTs) help in testing and validating the safety and efficacy of newly discovered drugs on specific patient population cohorts. However, these trials usually experience many challenges, such as extensive time frames, high financial cost, regulatory and administrative barriers, and insufficient workforce. In addition, CTs face several data management challenges pertaining to protocol compliance, patient enrollment, transparency, traceability, data integrity, and selective reporting. Blockchain can potentially address such challenges because of its intrinsic features and properties. Although existing literature broadly discusses the applicability of blockchain-based solutions for CTs, only a few studies present their working proof-of-concept.Methods: We propose a blockchain-based framework for CT data management, using Ethereum smart contracts, which employs IPFS as the file storage system to automate processes and information exchange among CT stakeholders. CT documents stored in the IPFS are difficult to tamper with as they are given unique cryptographic hashes. We present algorithms that capture various stages of CT data management. We develop the Ethereum smart contract using Remix IDE that is validated under different scenarios.Results: The proposed framework results are advantageous to all stakeholders ensuring transparency, data integrity, and protocol compliance. Although the proposed solution is tested on the Ethereum blockchain platform, it can be deployed in private blockchain networks using their native smart contract technologies. We make our smart contract code publicly available on Github.Conclusions: We conclude that the proposed framework can be highly effective in ensuring that the trial abides by the protocol and the functions are executed only by the stakeholders who are given permission. It also assures data integrity and promotes transparency and traceability of information among stakeholders. [ABSTRACT FROM AUTHOR]