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In this paper a new approach to optimize nuclear power plant designs based on global risk reduction are described. In design the focus is on as components quality as redundancy levels. Meanwhile in maintenance and test tasks the focus is on as scheduling tasks as human reliability. The models based on probabilistic risk analysis are used to evaluate several designs and schedules proposed by an hybrid genetic algorithm. The best alternative is chosen to minimize the economical risk of down the production or of have an accident for all reasons considered. This approach has resulted in a new methodology to assure the risk for complex industrial systems too in a global way. So, it is possible considering several aspects such as component qualities, redundancy levels, task schedules for maintenance or tests tasks, and reliability human as a whole. [ABSTRACT FROM AUTHOR]