1. Use of an Anopheles Salivary Biomarker to Assess Malaria Transmission Risk Along the Thailand-Myanmar Border.
- Author
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Ya-umphan, Phubeth, Cerqueira, Dominique, Parker, Daniel M., Cottrell, Gilles, Poinsignon, Anne, Remoue, Franck, Brengues, Cecile, Chareonviriyaphap, Theeraphap, Nosten, Francois, and Corbel, Vincent
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MALARIA diagnosis , *MALARIA treatment , *ANIMALS , *DISEASE vectors , *BIOMARKERS , *BITES & stings , *IMMUNOGLOBULINS , *INSECTS , *LONGITUDINAL method , *MALARIA , *PROTEINS , *ENVIRONMENTAL exposure - Abstract
Background: The modalities of malaria transmission along the Thailand-Myanmar border are poorly understood. Here we address the relevance of using a specific Anopheles salivary biomarker to measure the risk among humans of exposure to Anopheles bites.Methods: Serologic surveys were conducted from May 2013 to December 2014 in 4 sentinel villages. More than 9400 blood specimens were collected in filter papers from all inhabitants at baseline and then every 3 months thereafter, for up to 18 months, for analysis by enzyme-linked immunosorbent assay. The relationship between the intensity of the human antibody response and entomological indicators of transmission (human biting rates and entomological inoculation rates [EIRs]) was studied using a multivariate 3-level mixed model analysis. Heat maps for human immunoglobulin G (IgG) responses for each village and survey time point were created using QGIS 2.4.Results: The levels of IgG response among participants varied significantly according to village, season, and age (P<.001) and were positively associated with the abundance of total Anopheles species and primary malaria vectors and the EIR (P<.001). Spatial clusters of high-IgG responders were identified across space and time within study villages.Conclusions: The gSG6-P1 biomarker has great potential to address the risk of transmission along the Thailand-Myanmar border and represents a promising tool to guide malaria interventions. [ABSTRACT FROM AUTHOR]- Published
- 2017
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