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• This paper aims at quantifying the factors affecting vegetation growth in the western of Inner Mongolia, and judging the relative contribution of natural factors and man-made factors. • It is obtained through geodetectors (GD) that Rainfall is the most important driving factor, with the q-value of 0.77 and GDP also having a huge impact on vegetation growth, q-value of 0.64. • Different from most studies, human activity also has a positive effect on vegetation growth. • The relative contribution of human activities reached 51.75%, slightly exceeding the influence of natural factors. Vegetation is an essential component of terrestrial ecosystems, and understanding the drivers of vegetation change is of great importance for ecological management. In recent years, vegetation growth has increased under the combined effect of global warming and human activities in Inner Mongolia. The net primary productivity (NPP) was used as an indicator to study the spatial and temporal changes in vegetation in the Qimeng Region (QR). The residual trend analysis method was used to analyze the relative contributions of climate variations (CV) and human activities (HA) to NPP changes across the QR, while their drivers were explored using a geographical detector approach to quantify the driving forces of NPP. The results show that (1) NPP exhibited a fluctuating growth trend from 2003 to 2020, with an overall growth rate of 2.91%/year. (2) Precipitation, GDP and population density were the dominant driving factors for the spatial distribution of NPP. The combined explanatory power of any two dominant factors exceeded the power of any dominant individual factor, and the interaction between climate and human factors had a significant effect on NPP. (3) The change in NPP was influenced by the combined effect of HA and CV, accounting for 37.69% of the total area, with the relative contribution of HA being 51.75%. Finally, the relative contribution of human activities was slightly higher than that of climate change, confirming the initial success of the Grain to Green Program as well as ecological conservation projects. This paper provides a scientific basis for the local government to carry out the conversion of cropland to forest. [ABSTRACT FROM AUTHOR]