1. Upregulation of Soluble HLA-G5 and HLA-G6 Isoforms in the Milder Histopathological Stages of Helicobacter pylori Infection: A Role for Subverting Immune Responses?
- Author
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Oliveira Souza, D. M. B., Genre, J., Alves Silva, T. G., Soares, C. P., Borges Ferreira Rocha, K., Nunes Oliveira, C., Nunes Jatobá, C. A., Marco de Leon Andrade, J., Moreau, P., Cunha Medeiros, A., Donadi, E. A., and Oliveira Crispim, J. C.
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HLA histocompatibility antigens , *HISTOPATHOLOGY , *HELICOBACTER pylori infections , *IMMUNE response , *IMMUNOHISTOCHEMISTRY , *BACTERIAL colonies - Abstract
The subversion mechanisms employed by Helicobacter pylori ( H. pylori) to escape from immune surveillance and to establish persistent infection are poorly understood. Growing evidence indicates that expression of HLA-G, a non-classical major histocompatibility complex molecule, negatively regulates immune responses in pathological conditions, including infectious diseases. In this context, we aimed to evaluate HLA-G expression in the gastric microenvironment of individuals harbouring H. pylori and to correlate it with histological variables. Fifty-four gastric specimens from patients harbouring H. pylori infection were evaluated by immunohistochemistry using anti- HLA-G monoclonal antibody. As a result, HLA-G expression was detected in 43 of 54 specimens harbouring H. pylori. The presence of HLA-G was significantly associated with milder colonization by H. pylori ( P < 0.02), milder inflammatory activity ( P < 0.02) and bacterium histological location in the gastric antrum. This study is the first to explore HLA-G expression in the context of bacterial infection. Whether the biological role of HLA-G during H. pylori infection is beneficial or hazardous for patients remains to be defined. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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