10 results on '"周小平"'
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2. LncRNA FAM83A-AS1通过miR-150/HMGA2轴 对视网膜母细胞瘤细胞增殖和凋亡的影响.
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周小平, 彭正武, 陈书扬, 刘茹, 田涛, and 欧玉仑
- Abstract
Objective To investigate the role of long non-coding RNA family with sequence similarity 83 member A antisense RNA 1 in retinoblastoma (RB) cells and its potential molecular mechanism. Methods RB cells were cultured in vitro, and Vector, pcDNA-FAM83A-AS1, NC-siRNA, and FAM83A-AS1-siRNA were transfected into cells to detect the expression of FAM83A-AS1, RB cell proliferation ability, and apoptosis rate in RB cells. Bioinformatics and dual-luciferase reporter gene experiments were performed to predict and verify the targeting relationship between FAM83A-AS1 and miR-150, and miR-150 and the high-mobility family protein A2 (HMGA 2). The expression of miR-150 and HMGA2 mRNA in RB cells was measured by RT-qPCR; HMGA 2 protein in RB cells by Western blot; and the proliferation and apoptotic capacity of RB cells after transfection by MTT assay and flow cytometry. Results The expression of FAM83A-AS1 in the pcDNA-FAM83A-AS1 group was significantly higher than that of the Vector group and lower than that of the NC-siRNA group (P < 0.05). The cell proliferation capacity in the pcDNA-FAM83A-AS1 group was significantly higher, and the apoptosis rate was significantly lower (P < 0.05). Compared with NC-siRNA group, FAM83A-AS1-siRNA group showed significantly increased apoptosis rate (P < 0.05). The miR-150 mimic significantly inhibited the proliferation capacity of RB cells and promoted cell apoptosis. However, pcDNA-HMGA 2 significantly reversed the effect of miR-150 mimic on the proliferation and apoptosis of RB cells. Conclusion Knockdown of lncRNA FAM83A-AS1 inhibited RB cell proliferation and promoted apoptosis by regulating the miR-150/HMGA2 axis. [ABSTRACT FROM AUTHOR]
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- 2023
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3. 宁夏干旱带油用向日葵水肥耦合效应研究.
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何 玲, 周小平, and 杨艳芳
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The water-fertilizer (NP) coupling field experiment for oilseed sunflower was conducted in the drought of middle ningxia under the condition of drip irrigation by “312-D”saturation optimum design. The regressive maths model was set up based on the oilseed sunflower yield. Analysis showed that the effects among these factors were positive on the oilseed sunflower yield with the influenced order as water>N>P, interaction effects influenced order as N and water>NP>P and water, and P and water was negative. The optimum dosage combinations of water-fertilizer coupling: the dosage of N were 248. 03 kg / hm², P2O5 were 104. 06 kg / hm², K2O 60 kg / hm², irrigation was 888. 05 m³ / hm². Yield reached 4 918. 15 kg / hm², than local yield and income of oilseed sunflower increased by 29. 4% and 5 287 yuan / hm². [ABSTRACT FROM AUTHOR]
- Published
- 2023
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4. 主体功能区视角下长三角地区国土空间格局时空演变 及其碳排放效应分析.
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周小平, 李理, 梁颖, and 杨兰
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CARBON emissions , *ENVIRONMENTAL protection , *AGRICULTURAL development , *CARBON cycle , *ECOLOGICAL zones , *SPACE - Abstract
Main functional zone (MFZ) planning is one of the most important national strategies in economic development and ecological environment protection. It is very necessary to analyze the evolution characteristics of territorial space patterns and the carbon emission in the MFZ system. This study aims to determine the spatial and temporal evolution of territorial spatial patterns in the Yangtze River Delta region before and after the MFZ implementation using the land use data from 2000 to 2020. The spatial transfer of territorial space was then evaluated using carbon emission data and contribution rate analysis. The results show that: 1) Urban and ecological space continued to increase, whereas, the agricultural space decreased in the study area. The agricultural main production, the optimized and the key development zones were dominated by the transfer of agricultural production space, while the ecological function zone was dominated by the mutual conversion of forest ecological space and agricultural production space. The rate of change in the territorial space tended to slow down after the MFZ implementation. 2) Agricultural production space was the main type of transfer out, whereas, the transfer in was the agricultural living space, urban living space, and urban production space. There was a negative correlation between the increase and decrease in the number of spatial changes in the territory within each MFZ, indicating the significant spatial heterogeneity. 3) Net carbon emissions decreased (in C units) by 14 956.57 kg/(m² ·a) with a spatial distribution of high in the west and low in the east. Among them, the high-value areas were clustered and distributed in the key development zones and the agricultural main production zone. Regional agglomeration was enhanced by the net carbon emissions enhancement in the key development and ecological function zone. The reduction zone was distributed mainly in the main production areas of agricultural products. There was an increase in the number of carbon emissions that converted to carbon sinks on the grid scale after the MFZ implementation. 4) The reduced net carbon emissions were attributed to the conversion of agricultural production space into forest ecological space. There was a decrease in the carbon emissions in other main functional zones, due mainly to the conversion of agricultural living space to agricultural production space. Furthermore, the conversion of agricultural to urban space was attributed to the increase in carbon emissions in each subjective functional area. A diversified type of territorial space was attributed to the variations in the carbon emissions after the implementation of the MFZ planning. As such, the MFZ system should be further improved to reduce carbon but increase sinks in the territorial space. Territorial spatial planning should be compiled with the local conditions in low-carbon-oriented activities. Therefore, green and low carbon utilization can be realized with the goal of reducing carbon and increasing sinks in the territorial space. [ABSTRACT FROM AUTHOR]
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- 2023
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5. 生物炭-硅酸钙联合修复铅镉污染土壤的持续性效应.
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苏梦贤, 张磊, 周小平, 寇萌, 熊娟, 汪明霞, and 谭文峰
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This study evaluated the remediation effect and stability of palm biochar combined with calcium silicate on lead-cadmium(PbCd)co-contaminated soil, by determining the pH, Pb content, and Cd content in soil solution and edible parts of vegetables in pot experiments. The results demonstrated that compared with the control, addition of a passivation agent could effectively increase the pH value, and substantially reduced the Pb and Cd content in soil solution, and in the edible part of Chinese cabbage by 62.20%–96.77% and 92.76%, respectively. Most of the Pb and Cd contents in the edible part met the National Food Safety Standards(GB 2762—2022)after soil remediation. The results of planting suitability analysis revealed that there were consistent trends of heavy metal concentration in the edible parts and enrichment coefficients of the five tested vegetables. Chinese cabbage and amaranth had the strongest accumulation ability for Pb and Cd, respectively. Soil with Pb<500 mg·kg-1, was more suitable for planting Chinese chives, amaranth, cabbage, and Chinese cabbage; whereas soil with Cd>0.6 mg·kg-1 and/or Pb>500 mg·kg-1, was not suitable for planting any of the five vegetables. This study proves that the continuous remediation effect of the passivator provides technical reference for soil remediation, as well as suggestions for suitable vegetable planting in low-medium pollution risk areas. [ABSTRACT FROM AUTHOR]
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- 2024
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6. 高速运动裂纹扩展和分叉现象的 近场动力学数值模拟.
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谷新保, 周小平, and 徐 潇
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The peridynamic theory was first introduced, then 2 examples of high-speed crack propagating and branching phenomena were given and investigated. The effects of peridynamic parameters including the neighbourhood radius and the grid spacing, and such external parameters as the material elastic modulus, the material density and the temperature difference, on the crack propagating velocity and the crack branching angle were analyzed. It is found from the numerical results that the crack propagating velocity decreases and the crack branching angle increases with the neighbourhood radius; both the crack propagating velocity and the crack branching angle decrease with the grid spacing; the crack branching length in the material of a smaller elastic modulus and a larger density is longer; the crack propagating velocity increases with the elastic modulus difference; the crack propagating velocity increases as the materials'density difference decreases, and decreases with the temperature difference. Moreover, the crack propagating and branching process can be simulated with the peridynamic method spontaneously, without any outer criterion and preset crack propagating paths. Therefore, peridynam-ics has natural advantages in the simulation of high-speed crack propagating and branching phenomena. [ABSTRACT FROM AUTHOR]
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- 2016
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7. TBM 破岩机理的三维 FEM-SPH 耦合算法.
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肖南, 周小平, 程浩, and 翟淑芳
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FME-SPH coupling method was applied to simulate the mechanism of rock fragmentation by TBM cutters. The 3D coupling models of rock fragmentation by single TBM cutter and two TBM cutters were established. The mechanism of rock fragmentation by TBM cutters was analyzed. The conclusions are summarized as follows: for the rock fragmentation by single TBM cutter,in the stage of the formation of the crused zone,beneath the thrust of a single cutter,microcracks extend downward to form a fan-shaped failure zone;beneath the tangential force of a single cutter,microcracks propagate forward to form the other fan-shaped failure zone. The two fan-shaped failure zones consist of a conical failure zone in rock. In the stage of the formation of microcracks,the growth rate of radial crack is faster than that of median crack. In the stage of the propagation of microcracks,the growth rate of median crack is faster than that of radial crack. When the cutter scrolls to the edge of rock,the fan-shaped failure occurs on the edge of rock. for the rock fragmentation by two TBM cutters,in the initial stage,each cutter independently acts on the rock. A conical failure zone is first formed beneath each cutter. In the stage of the formation of microcracks,the propagation direction of the Hertzian cracks between two cutters are changed because of the interaction of two cutters. In the stage of the propagation of microcracks,Hertzian cracks between the two cutters coalesce,then the rock chipping is formed. [ABSTRACT FROM AUTHOR]
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- 2015
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8. 大都市郊野乡村多功能评价及其空间布局 --以上海89 个郊野镇为例.
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谷晓坤, 陶思远, 卢方方, and 周小平
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INNER cities , *COMMUNITY development , *INDUSTRIAL efficiency , *AGRICULTURAL productivity , *SUBURBS , *RURAL population - Abstract
With the rapid development of industrialization and urbanization as well as enhancement of geographic differentiation and diversity of man-earth areal system, functions and regional development orientations in metropolitan suburbs have shown an increasingly strong trend towards diversification. It is one of the keys to draw up the Rural Revitalization policy objectively to evaluate the multi-functional system and then sum up pattern of metropolitan suburbs. The multi-functional evaluation method of metropolitan suburbs was constructed. The multi-source spatial data, statistical data and survey data were used to evaluate the multi-functional values of the 89 towns in Shanghai. The results showed that: (1) There were significant differences in the development of multifunction among 89 towns in Shanghai. The order of mean values is listed as ecological environment function (0.7674) > economic development function (0.6054) > agricultural production function (0.5882) > life guarantee function (0.5238) > leisure culture function (0.2525). (2) The high value areas of the ecological environment were mainly distributed in Chongming Island, Western Qingpu and Southern Fengxian. The high value areas of agricultural production were mainly located in Southern Pudong, Fengxian, Jinshan, Southern Chongming and Qingpu. The high value areas of economic development was mainly located in the vicinity of central city. The low value areas of life security were mainly located in the towns close to the central city and the most remote towns. The high value area of leisure culture was mainly located in Songjiang, Qingpu and Jinshan, which are the most remote from the central city. (3) A total of 89 towns could be divided into 4 types: balanced, mixed, compound and dominant. Among the 8 subdivision patterns, only 10 towns like Pujiang town were multi-functional and presented a highly balanced development pattern, accounting for 11.24%. Thus, the final but main part of this paper envisions the innovative policies and practices in metropolitan suburbs including the diversified rural renewal, homestead regulation, and low efficiency industrial land reduction. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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9. PDCA 教学模式在门诊采血室实习护生职业暴露中的应用.
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杜小玉, 王寿翠, 周小平, 白鍊, 陈小玉, and 王春容
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目的分析PDCA带教模式在提高门诊采血室实习护生的职业防护意识、降低血源性传染病暴露率中的临床意义。方法将2015年该院门诊采血室实习的50名护生随机分成传统组(24名)和试验组(26名),传统组采用传统模式进行教学,试验组采用PDCA教学法对护生进行带教,对比两组实习护生发生职业暴露情况和护生对教学的满意度。结果传统组实习护生的职业暴露率为25.00%,满意度为70.83%,试验组护生的职业暴露率为0,满意度为96.15%,两组比较,差异均有统计学意义(P<0.05)。结论PDCA教学模式能够有效控制实习护生的职业风险,同时提高实习护生对教学的满意度,深受护生的好评。 [ABSTRACT FROM AUTHOR]
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- 2017
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10. Massworks™结合NIST11谱库在羊油香气成分准确定性分析中的应用.
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齐安安, 马灵飞, 雷春妮, 张雅珩, 马鑫, 庞伟强, and 周小平
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MassworksTM mass spectrometry combined with NIST11 library was used to the quasi-deterministic analysis of the aroma components of goat oil. Mass spectrometry correction function was established using the mass spectrogram of perfluorotributylamine (PFTBA) as a standard in MassworksTM mass spectrometry analysis software. Then, the mass-axis correction and peak shape correction were performed on the original scanning chromatogram of the sample collected by TD-GC/MS. The accurate mass of each compound was obtained on a low-resolution mass spectrum, and the molecular formulas of unknown target compounds were obtained by isotope peak shape correction technology (CLIPs Search). The target compounds were determined by comparing the results of MassworksTM and NIST11 library search. Finally, the results of MassworksTM mass spectrometry software and NIST11 library search were verified by standards. The results showed that the combination of MassworksTM and NIST11 libraries enabled fast and quasi-deterministic analysis of the aroma components of goat oil. Through the background subtraction function and parameter optimization of MassworkTM software, ion fragment information of compound can be obtained and analyzed to obtain the exact molecular weight and molecular formula of the target compound. In this experiment, qualitative analysis was conducted for the aroma components of different parts of the sheep body. Finally, 42 aroma components of sheep oil were identified, including 15 kinds of hydrocarbon, 14 kinds of aldehydes, 4 kinds of alcohols, 3 kinds of ketones, 2 kinds of lipids, 2 kinds of ethers, and 2 kinds of other substances. Their relative contents were compared using the area normalization method. This method not only solved the qualitative uncertainty of the natural product aroma components and the uniqueness of the NIST11 spectral library, but also provided a reference for the consumption of sheep oil and the separation of aroma components. On the other hand, the qualitative analysis method can provide new ideas and references for the analysis of aroma components of natural products in the future. The quasi-determinacy of the aroma components of sheep oil in animal oil can be used as an effective qualitative method to achieve simple and accurate qualitative analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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