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Existing CNN-based video anomaly detection methods improve the accuracy continuously, which are faced with issues such as complex architecture, large parameters and lengthy training. Therefore, the hardware computing power requirements of them are high, which makes it difficult to adapt to edge devices with limited computing resources like UAVs. To this end, this paper proposed a lightweight abnormal event detection method for edge devices. Firstly, the method extracted gradient cuboids and optical flow cuboids from video sequence as appearance and motion feature representation; Secondly, the method designed a modified PCANet network to obtain high-level block-wise histogram features of gradient cuboids; Then, the method calculated the appearance anomaly score of each block based on histogram feature distribution, and calculated the motion anomaly score based on the accumulation of optical flow amplitudes of internal pixels; Finally, the method fused the appearance and motion anomaly scores to identify anomalous blocks, achieving appearance and motion abnormal events detection and localization simultaneously. The frame-level AUC of proposed method reached 86.7% on UCSD Ped1 dataset and 94.9% on UCSD Ped2 dataset, which were superior to other methods and the parameters are much smaller. Experimental results show that the method achieves better anomaly detection performance under low computational power requirements, making the balance between detection precision and computing resources, which is suitable for low-power edge devices. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of extracorporeal shock wave lithotripsy (ESWL) on procalcitonin (PCT), renal function and inflammatory index levels in patients with indinavir-induced urinary calculi so as to provide reference for clinical practice. Methods A total of 77 patients with urinary calculi admitted to the Department of Urology of our hospital from January 2017 to January 2021 were selected for retrospective analysis. They were divided into control group (38 cases, non-indinavir related urinary calculi） and observation group (39 cases, indinavir-related urinary calculi) according to the years of the disease. Before treatment and 7 days after treatment, the serum levels of PCT, CRP, Scr, UA, Kim1, VAS scores, and IgG, IgM, MDA, and SOD levels were compared between the two groups. Results The expressions of serum PCT and CRP at 7 days after treatment in the two groups were significantly lower than those before treatment, and the improvement degree of the observation group was significantly higher than that in the control group (P＜0.05). The renal function indexes of urine Kim-1, Scr and BUA in the control group after treatment were significantly better than those in the observation group (P＜0.05). However, there was no significant difference in VAS score between the two groups before and after treatment (P＞0.05), but the intraoperative blood loss and MAP 20 min after induction of anesthesia were significantly better than those in the control group. Seven days after treatment, GSH-Px and SOD were significantly better in the observation group than in the control group and before treatment (P＜0.05). Conclusion ESWL treatment for patients with indinavir-induced urinary calculi can effectively reduce the expressions of serum PCT and CRP, improve renal function indexes, reduce intraoperative blood loss, and reduce the level of inflammatory indexes;the clinical effect is good. [ABSTRACT FROM AUTHOR]

Objective：This study aims to investigate the effects of a novel hybrid compound CDDO ⁃NO from bardoxolone methyl （CDDO⁃Me）and NO donor isosorbide 5⁃mononitrate on monocrotaline（MCT）⁃induced pulmonary arterial hypertension（PAH）in rats. Methods：Male Sprague⁃Dawley rats were randomly divided into 6 groups：control（Con）group，MCT group，MCT+10 μg/kg CDDO⁃NO （MCT+10NO）group，MCT+30 μg/kg CDDO⁃NO（MCT+30NO）group，MCT+7 μg/kg CDDO⁃Me（MCT+7Me）group and MCT+21 μg/kg CDDO⁃Me（MCT+21Me）group. PAH in rat was induced by a single dose injection of 60 mg/kg MCT intraperitoneally. The rats in each treatment groups were treated for daily aerosol CDDO ⁃NO or CDDO ⁃Me inhalation for 28 days. Right ventricular systolic pressure （RVSP）by right heart catheter，and right ventricular hypertrophy index（RVHI）as well as RV ⁃to ⁃ body weight ratio（RV/BW）were measured. Hematoxylin⁃eosin（HE）staining was used to detect the pulmonary artery medial thickness（PAMT）and the morphological changes of the right ventricle. And α⁃smooth muscle actin（α⁃SMA）immunohistochemistry was used to investigate the muscularization of distal vessels. Masson’s trichrome staining（MTS）was performed to evaluate the fibrosis of arterioles. Results：Right heart catheter and right ventricular remodeling indicators showed that inhalation of either CDDO⁃NO or CDDO⁃Me suppressed elevations of RVSP， RVHI and RV/BW induced by MCT in PAH rats. CDDO⁃NO（30 μg/kg）showed stronger inhibitory effect in RVHI and RV/BW than that of the equal dose of parent compound CDDO⁃Me（21 μg/kg）. Moreover，pathological studies indicated that 30 μg/kg CDDO⁃NO had better effects in alleviating right ventricular myocardial hypertrophy and PAMT，and reducing the proportion of fully muscularized vessels and the area of collagen deposition than those of CDDO⁃Me（21 μg/kg）. Conclusion：Inhalation of CDDO⁃NO can ameliorate MCT⁃induced PAH in rats by inhibiting pulmonary vascular remodeling，and the effect of CDDO⁃NO is superior to parent compound CDDO⁃Me. These results suggest that CDDO⁃NO could be a promising drug for the treatment of PAH. [ABSTRACT FROM AUTHOR]

Most research studies on forecasting of earthquakes focus on thermal or electrical aspects. Scholars have proved GPS time series also contains precursory information for large earthquakes. For the problems mentioned before, three typical earthquakes hit America from 2001 to 2010 were investigated by using GPS data of several GPS reference stations near the epicenters. This paper proposed an algorithm based on Martingale theory to detect the anomalies in GPS data. The experimental results show that the proposed algorithm can effectively reflect the change process in GPS data before and after large earthquakes, which offers more possibilities for earthquake forecast from GPS data. [ABSTRACT FROM AUTHOR]

Objective To evaluate the effects of electroacupuncture on clinical efficacy, changes of serum vascular endothelial growth factor (VEGF) and neuron specific enolase (NSE) in patients with acute cerebral infarction. Methods From January 2015 to June 2016, 96 patients with acute cerebral infarction were selected and randomly divided into control group (48 cases) and electroacupuncture group (48 cases). The control group was given routine treatment, and the electroacupuncture group was given acupuncture combined with scalp acupuncture and body acupuncture on the basis of routine treatment for two weeks. The clinical efficacy, NIHSS score, serum VEGF and NSE levels were evaluated in two groups of patients. Results After two weeks of treatment, the clinical effective rate was higher in electroacupuncture group than that of the control group (P<0.05). After one week and two weeks of treatment, the NIHSS score and serum NSE level were significantly decreased in both groups of patients compared with those before treatment (P<0.05). The NIHSS score and serum NSE level were lower in the electroacupuncture group than those in the control group (P<0.05). After one week and two weeks of treatment, serum VEGF levels were significantly increased compared with those before treatment in the two groups (P<0.05). The serum VEGF level was higher in electroacupuncture group than that in control group (P<0.05). Conclusion Electroacupuncture treatment can promote the regeneration of damaged blood vessels, repair neurons and improve clinical efficacy in patients with acute cerebral infarction, which shows definite clinical significance. [ABSTRACT FROM AUTHOR]

To observe the performance of human epididymis protein 4 (HE4), aldehyde dehydrogenase 1 (ALDH1) and adhesion molecule CD44 in differential diagnosis of benign and malignant ovarian tumors. 100 patients with ovarian carcinoma and 100 patients with benign ovarian tumor who were admitted to the hospital from January 2020 to May 2022 were selected, and included in the malignant group and the benign group. At the same time, 100 healthy women were selected as the control group. The expression of HE4 and ALDH1 in serum and CD44 in tissues of the three groups was compared. The value of the three parameters in differential diagnosis of benign and malignant ovarian tumors was analyzed using the receiver operating characteristic (ROC) curve. The levels of HE4 and ALDH1, and CD44 positive expression rate decreased in order from the malignant group, the benign group to the control group (P<0.05). For the malignant group, the levels of HE4 and ALDH1, and CD44 positive expression rate were higher in patients with clinical stage III-IV and lymph node metastasis than those with clinical stage I-II and without lymph node metastasis (P<0.05). Spesrman correlation analysis found that the levels of HE4 and ALDH1, and CD44 positive expression rate were positively correlated with clinical stage and lymph node metastasis in patients with ovarian carcinoma (P<0.05). ROC curve analysis results showed that the area under the curve (AUC) values of HE4, ALDH1, and CD44 in differential diagnosis of benign and malignant ovarian tumors were 0.837, 0.768, and 0.610, respectively. The AUC and sensitivity of combined diagnosis with the three indicators were higher than those of single diagnosis (P<0.05). The expression of HE4 and ALDH1 in serum and CD44 in tissues of patients with malignant ovarian tumors is high. The expression level is closely related to clinical stage and lymph node metastasis of ovarian carcinoma. The combination of HE4, ALDH1 and CD44 is of high value in the differential diagnosis of benign and malignant ovarian tumors. [ABSTRACT FROM AUTHOR]

The modernization process of agriculture has led to serious agricultural non-point source pollution. It is a new direction to study the evaluation framework of agricultural production efficiency by including the ecological environment effect of agriculture. Agricultural eco-environmental efficiency which combines both economic and ecological performance is a valid way for agricultural sustainability analysis. Based on the non-radial and non-angle SBM-DEA model and the directional distance function, the agricultural eco-environmental efficiency of the Three Gorges Reservoir area in Chongqing during the period from 2003 to 2015 was investigated. The marginal price of agricultural non-point source pollution was estimated by introducing the shadow price cost of emission reduction. The results showed that: 1) During the period of 2006 to 2015, the agro-ecological environment efficiency of the Three Gorges Reservoir area in Chongqing tended to increase steadily, but the overall level was low；2) The input and output of each district (county) were needed to change to optimize the efficiency of agro-ecological environment. The areas with high agro-ecological environment were concentrated in the urban core area and the urban fringe of the reservoir, while the eco-environmental efficiency of the low mountain and hill area, parallel ridge valley area, mountainous area in the hinterland and surrounding mountain area in the hinterland were relatively low; 3) From the reasons of the efficiency loss, the excessive use of chemical fertilizers and pesticides and their corresponding adverse ecological and environmental effects were outstanding, mainly due to the inefficiency of agricultural investment and the inefficiency of undesired output; 4) The shadow prices of agricultural non-point source pollution in Dadukou, Nan’an, Jiangbei, Beibei and Yubei area were at the forefront, and the pollution abatement space was small, therefor, the task of reducing agricultural non-point source pollution should be commissioned. Fengdu, Kaixian and Wanxian district’s shadow prices of agricultural non-point source pollution emission were low, thus those three areas should be assigned to agricultural non-point source pollution reduction. Chongqing section of Three Gorges Reservoir Area had an enormous potential for reduction of agricultural non-point source pollution and for the decrease of resource inputs to enhance the agricultural eco-environmental efficiency. Agricultural eco-environmental efficiency evaluation plays an important role in promoting agriculture ecological and sustainable development. The eco-environmental efficiency optimization provides further implications on resource and environmental protection strategies in Chongqing section of Three Gorges Reservoir Area. Meanwhile, we should evaluate agricultural eco-environmental efficiency according to resources endowment, factor substitution, adverse impact on ecology and environment and consider the regional development and different stages, we should promote differently the development of ecological agriculture. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To compare the clinical efficacy between Butylphthalide capsules and butylphthalide sodium chloride injection in treatment of acute cerebral infarction. METHODS: Totally 120 patients with acute cerebral infarction admitted into the Sixth People’s Hospital of Huizhou from Apr. 2016 to Apr. 2018 were extracted to be divided into group A and group B via the random number table, with 60 cases in each group. Patients in group A were treated with Butylphthalide capsules, while the group B received butylphthalide chloride injection. Differences of national institutes of health stroke scale score(NIHSS), Barthel index score, clinical efficacy, occurrence of adverse drug reactions and treatment costs were compared between two groups. RESULTS: After treatment, compared with group A, patients in group B had lower NIHSS score and higher Barthel index score, the difference was statistically significant(P<0.05). Compared with group A, the total effective rate of group B was higher, and the difference was statistically significant(P<0.05). During the treatment, the incidence of adverse drug reactions in both groups was 10.00%(6/60), with no statistically significant difference(P>0.05). The average treatment costs in group A was(480.63±124.06) yuan, significantly lower than(674.53±185.23) yuan in group B, and the difference was statistically significant(P<0.05). CONCLUSIONS: The efficacy of butylphthalide sodium chloride injection is better than that of Butylphthalide capsules in treatment of acute cerebral infarction. The butylphthalide sodium chloride injection can effectively reduce the degree of nerve defect in patients with acute cerebral infarction, improve the ability of daily life and promote the treatment effects, but the treatment costs are relatively higher. [ABSTRACT FROM AUTHOR]

Objective: To study the value of serum albumin / globulin ratio (AGR), carcinoembryonic antigen (CEA), glycoantigen (CA) 199 and macrophage inhibitory cytokine-1 (MIC-1) expression in the diagnosis and prognostic evaluation of elderly colorectal cancer. Methods: 60 cases of elderly colorectal cancer patients admitted to our hospital from March 2020 to December 2022 were selected as the observation group. According to the prognosis of patients, they were divided into good prognosis group (36 cases) and poor prognosis group (24 cases), and 58 healthy patients to our hospital for physical examination in the same period were selected as the control group. We compared AGR, CEA, CA199 and MIC-1 expression levels in the observation and control groups, compared the AGR, CEA, CA199,1 and MIC-1 expression levels, general clinical data between the good and poor prognosis groups, and analyzed the relationship between AGR, CEA, CA199 and MIC-1 expression and prognostic outcome in elderly colorectal cancer patients by Logistic regression model. Results: Comparison of previous targeted therapy, gender, age, tumor family history, tumor location, distance between tumor and anal margin in patients with poor prognosis, Not statistically significant difference (P>0.05), Patients in the good prognosis group with high differentiation, TNM stage ⅠⅡ and lymph node metastasis were lower than the poor prognosis group, Statistically significant difference (P<0.05), The AGR in the good prognosis group was higher than that in the poor prognosis group, Statistically significant difference (P<0.05), CA199, CEA level, and positive MIC-1 expression were lower than those in the poor prognosis group, Statistically significant (P<0.05) observation group patients had lower AGR than the control group, Statistically significant difference (P <0.05), The proportion of CA199, CEA level and positive MIC-1 expression were higher than those in the control group, Statistically significant difference (P<0.05), Logistic The regression analysis showed TNM stage, AGR, CEA, and CA199 as the factors influencing the prognosis of elderly colorectal cancer patients (P<0.05). The ROC area under the curve of Logistic regression model jointly predicting poor prognosis in elderly colorectal cancer patients was 0.954, which was significantly higher than the area of 0.683, 0.866, 0.918, and 0.909 (P<0.05). Conclusion: Decreased serum AGR and increased CEA and CA199 levels are related to poor prognosis in elderly colorectal cancer, and the combination of various indicators can predict poor prognosis in elderly colorectal cancer patients. [ABSTRACT FROM AUTHOR]

Segmented multi cluster fracturing is an important process for effective production of unconventional oil and gas reservoirs. The complexity of fracturing fractures is the basis for improving single well production and controlling reserves. The expansion of reservoir fractures is more complex affected by formation physical properties and fracturing process parameters. In order to explore the morphological characteristics and influencing factors of synchronous propagation of fracturing cluster fractures, a mathematical model of segmented fracturing plane slit displacement parameters controlling double cluster fracture propagation is established. Through the core mechanical experiment and numerical simulation of typical wells, the results show that: (1) the synchronous propagation of segmented fracturing cluster fractures is closely related to the well deviation angle. When the well deviation angle is reduced from 90° to 0°, the fracture propagation morphological characteristics change from symmetrical to asymmetric. At 90°, the cluster fractures deflect outward, and the directions of the maximum and minimum principal stresses turn at the fracture tip and stress shadow area, which is more conducive to the formation of complex fracture network; When it is less than 90°, the slit deflects to the inside. (2) The intensity of stress interference between clusters of staged fracturing is positively correlated with the fracturing displacement and negatively correlated with the distance between clusters. Fracturing displacement has an obvious effect on increasing the expansion distance of fracture length and width, which can effectively improve the controlled reserves range of a single well, but there is an upper limit on the expansion of fracture width; When the cluster spacing is 10 m, the displacement of each hole is not less than 0.12 m³/min to effectively form the stress interference between clusters; When the displacement is 0.18 m³/min and the distance between clusters is less than 20 m, the stress interference between slit is significant, and the directions of the maximum and minimum principal stresses turn, which is better to form a complex joint network. When the distance between clusters is greater than 20 m, it is not conducive to the formation of a complex joint network. (3) The microseismic fracture detection confirms that the numerical simulation results are consistent with the fracture propagation distance of the adjacent well microseismic detection. Staged fracturing can effectively improve the complexity of the fracture network of unconventional oil and gas reservoirs, and improve the production and control reserves of unconventional resource by increasing the well inclination, increasing the fracturing displacement and reducing the cluster spacing. [ABSTRACT FROM AUTHOR]

内质网中的蛋白质处理、修饰和折叠受到严格调控,对细胞的功能和生存起决定作用。在过去 的十年中,细胞外应激和细胞内 DNA 损伤已经被证明会扰乱蛋白质平衡,导致内质网应激 (ERS),ERS 参与包 括胶质瘤在内的多种类型肿瘤的发病机制。在 ERS 的诱导下,肿瘤细胞激活非折叠蛋白反应 (UPR) 以恢复内 质网稳态或诱导细胞凋亡。近年来,UPR 的调控已经成为神经胶质瘤治疗的新靶点。该文将探讨 ERS 在胶质 瘤发生、进展中的作用,以及目前 UPR 相关修饰剂作为新的潜在治疗靶点的新进展。 [ABSTRACT FROM AUTHOR]

BACKGROUND: There are few studies, especially in China, addressing the correlation between exosome miRNAs and graft-versus-host disease (GVHD) following human hematopoietic stem cell transplantation. Exosome-derived nucleic acid molecules are expected to become new biomarkers for predicting the occurrence of acute GVHD (aGVHD). OBJECTIVE: To investigate the differential expression of candidate gene microRNAs in peripheral blood serum exosomes of aGVHD patients with after allogeneic hematopoietic stem cell transplantation. METHODS: A total of 30 patients with aGVHD and without aGVHD after allogeneic hematopoietic stem cell transplantation from August 2017 to May 2018 were enrolled, including 20 in aGVHD group and 10 in non-aGVHD group. Serum exosomes and miRNAs were extracted before and after transplantation. Image acquisition and data analysis were performed after gene chip hybridization. RESULTS AND CONCLUSION: After microarray hybridization microRNAs showed an over 10-fold upward or downward trend before and after transplantation. Compared with the control group, 11 microRNAs increased and 26 decreased in the aGVHD group. hsa-miR-3976, hsa-miR-122-5p, and hsa-miR-3125 were significantly up-regulated, while hsa-miR-941, hsa-miR-4687-5P and hsa-miR-4769-5p were significantly down-regulated. [ABSTRACT FROM AUTHOR]

The plate non-parallelism error of capacitance displacement sensor is studied to improve the thrust measurement accuracy of space-borne micro-thrusters. The relation between the plate nonparallelism error and variable torsional angle is analyzed by taking a typical torsion balance for example. Based on the property of that the plate non-parallelism error and width cosine error are all independent of the direction of torsional angle, a calibration method is presented, and an experimental instrument is designed. A sensor with range of 1mm and effective radius of 3.5mm is calibrated with an increment of 0.5°, and the deviation between the non-parallelism error and its theoretical value is 17.4%. The calibrated results show that the measured thrust error derived from non-parallelism error is rapidly increased to 3.25% when the steady-state torsional angle gets close to the maximum negative angle; and it is gradually increased to 0.04%, corresponding to the measured thrust error of 0.1 μN, when the steady-statetorsional angle gets close to the maximum positive angle; the effective radius of plate is not more than 7mm when the measured thrust error is less than the order of magnitude of μN. [ABSTRACT FROM AUTHOR]

Objective: To compare the difference and value of mammography and ultrasound examination in the diagnosis of early stage breast cancer in elderly. Methods: Elderly patients with early breast cancer in our hospital from August 2014 to June 2016 were selected. Retrospectively analysed the diagnosis of difference and value of breast cancer by breast X-ray (mammography) results and breast ultrasound examination in the breast cancer. Results: The molybdenum target is more sensitive to calcification than the ultrasound, and the detection rate of the ultrasound is higher than that of the molybdenum target. © For small tumors (diameter were between 0.5-2.0 cm), the ultrasound detection rate was higher than that of molybdenum target. And for the naked eye visibility and the can be palpable breast mass (diameter >2.0 cm), the detection rate of the two methods had no significant difference. ® There was no significant difference in the diagnostic rate of breast cancer between the molybdenum target and ultrasound. But the accuracy rate of the molybdenum target combined ultrasound in the breast cancer was higher than that of the molybdenum target. Conclusions: The two methods have their advantages and disadvantages in the assistant examination of early breast cancer in elderly. The combined application of the two methods can achieve the goal of increasing the accuracy of diagnosis. [ABSTRACT FROM AUTHOR]

Objective: In order to further study the effect of biology behavior of the gene 14-3-3θ to breast cancer, to build a recombinant vector and breast cancer cell line which can over express gene 14-3-3θ. Methods: The gene 14-3-3θ in the pENTR 3C DUAL is synthesized by a company, we put the gene 14-3-3θ into the vector pcDNA4.0 which can product 14-3-3θ in eukaryotic cells by recombinant DNA technology and then transfect the 293T, we identify the overexpression of the recombinant vector by the western blot and PCR. At last, we transfect the breast cancer cell by the recombinant vector and screen the breast cancer cell with Zeocin. Results: Successfully construct the recombinant vector and breast cancer cell line which can over express 14-3-3θ. Which shows that gene 14-3-3θ may play an important role in the early diagnosis and prognosis of breast cancer prediction. [ABSTRACT FROM AUTHOR]