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The present study is a safety survey of patients with human epidermal growth factor receptor type 2-positive, chemotherapy-naive breast cancer treated with trastuzumab plus paclitaxel at the Saitama Cancer Center (Saitama, Japan) between April 2018 and March 2022. The expression of infusion reaction (IR) and the effect on cardiac function were investigated in patients who switched from reference trastuzumab (HERCEPTIN®) to biosimilar trastuzumab (Trastuzumab-NK) and continued treatment (switching group). The two groups (reference vs. biosimilar trastuzumab) had no significant difference in the expression of IR (P>0.999). In the switching group, IR associated with switching did not occur in all nine eligible patients. Left ventricular ejection fraction (LVEF) was used to assess cardiac function, and no patient in either group experienced a significant decrease in LVEF with treatment, meaning that there was no effect of switching on the decrease in LVEF. These results suggested that switching from reference to biosimilar trastuzumab may not have a significant effect on the frequency of IR expression or the occurrence of cardiac dysfunction. [ABSTRACT FROM AUTHOR]

HML ( Hypsizigus marmoreus lectin) was isolated from the mushroom Hypsizigus marmoreus using CM cation exchange, bovine submaxillary gland mucin affinity column and TSK-GEL G3000SW gel filtration chromatography. The results of SDS-PAGE, MALDI-TOF MS and gel filtration analysis of HML indicated that the lectin was a dimer with each subunit of 9.5 kDa. The partial amino acid sequences of HML were determined by N -terminal sequencing of peptides obtained by trypsin or Glu-C endopeptidase digest of the lectin. In the hemagglutination inhibition assay, HML did not bind to any mono- or oligo-saccharides tested. Among the glycoproteins examined, asialo-fetuin was the strongest inhibitor. [ABSTRACT FROM AUTHOR]

Ongoing climate change has increased the impact of landslides and related slope disasters on infrastructure and human lives. Microwave satellite remote sensing, particularly interferometric analysis of synthetic aperture radar (InSAR) data, is a powerful tool for routine monitoring of the displacement of slopes on small wavelength scales, independently from solar illumination and cloud coverage. Although various sophisticated techniques for time-series InSAR have been developed, practical application in conjunction with geological analysis to reveal intrinsic and triggering factors of slope displacement is still limited. In this paper, we describe a practical case of time-series InSAR analysis with a special focus on its geological implications in northwestern Kyushu, a high-risk area for slope-related disasters in Japan. The extracted susceptible polygons from the InSAR results show accuracy comparable with that of other recent research on landslide mapping. Intrinsic factor analysis based on a geographic information system reveals that the displacement occurs on relatively gentle slopes instead of steep areas, corresponding to the transient zone of Paleogene-Neogene sedimentary rocks and basalt. Triggering factor analysis based on correlation coefficients reveals a significant link between some displacement areas with mean and/or maximum precipitation for each observation duration. Those findings confirm the importance of carefully accounting for the geological background for landslide susceptibility assessment and policy making, apart from topographic and meteorological conditions. [ABSTRACT FROM AUTHOR]

Purpose: Sarcopenia influences the short- and long-term outcomes of various medical conditions including malignancy. Ishii's screening test estimates the probability of sarcopenia based on a score calculated by three simple variables: age, grip strength, and calf circumference. We investigated the clinical significance of Ishii's score for patients with non-metastatic obstructive colorectal cancer (OCRC) who underwent curative surgery after intraluminal decompression. Methods: Ishii's score was calculated in 79 patients with OCRC. Muscle volume loss and decreased muscle quality were evaluated by computed tomography (CT) images as skeletal muscle index (SMI) and intramuscular adipose tissue content (IMAC), respectively. Results: There were 46 men and 33 women, with a median age of 70 years old. The cutoff value for Ishii's score was 155.1 and 15 patients were in the high-score group. The high-score group was significantly associated with worse time to recurrence (TTR) and overall survival (OS), and a high Ishii's score was an independent negative prognostic factor for TTR (hazard ratio = 2.93, P = 0.015). A high Ishii's score was significantly associated with a low SMI value but not with the IMAC value. Conclusion: A high Ishii's score was independently associated with poorer TTR in patients with non-metastatic OCRC. [ABSTRACT FROM AUTHOR]

• Sleep deprivation (SD) has been shown to decrease cognitive function. • We evaluated the acute effectiveness of exercise on cognitive function after SD. • Cognitive function was measured using a color word Stroop task. • Exercise can improve cognitive function after SD. We evaluated the effects of moderate-intensity exercise in improving the decline in cognitive performance induced by a 24-h period of acute sleep deprivation (SD). We hypothesized that the positive effect of exercise is mediated by increased oxygenation (measured using near-infrared spectroscopy) of the dorsolateral prefrontal cortex (DLPFC). Cognitive performance was measured using the reaction time and interference scores of the Stroop colour and word test, in 12 healthy adults (eight males, 21.1 ± 0.3 years-old), at pre- and post-exercise. Cognitive scores were compared under two conditions: rested wakefulness (RW) and 24-h SD. The exercise consisted of 20-min of ergometer cycling at an intensity of 60 % VO 2peak. Oxygenation to the DLPFC increased, at 12 min after exercise onset, compared to the baseline and was maintained until the end of the exercise in both RW and SD conditions (P < 0.01). The change in RT correlated with sleepiness (P < 0.05), with no correlation for the interference score and oxygenation. Taken together, moderate-intensity exercise reverses SD-induced cognitive decline. [ABSTRACT FROM AUTHOR]

Purpose: Inflammation is one of the hallmarks of cancer, and inflammation-based markers that are calculated easily from laboratory results have shown predictive abilities. We investigated the prognostic values of the preoperative platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV) in patients with non-metastatic obstructive colorectal cancer (OCRC) and a self-expandable metallic stent inserted as a bridge to curative surgery. Methods: The subjects of this retrospective study were 86 patients with pathological stage I to III OCRC. We examined the associations of these biomarkers with short- and long-term outcomes. Results: Multivariate analyses revealed that a preoperative PLR < 149, SII < 597, and PIV < 209 were independently associated with poorer relapse-free survival (RFS) (P = 0.007, P < 0.001, and P = 0.002, respectively) and that a PIV < 209 was independently associated with poorer cancer-specific survival (P = 0.030). A platelet count < 240 was significantly associated with worse RFS, whereas the lymphocyte count was not. Pre-stenting PLR < 221 was an independent poor prognostic factor for RFS (P = 0.045). Conclusion: This study showed that decreased preoperative PLR, SII, PIV, and pre-stenting PLR were associated with poorer RFS, contrary to the findings of most previous studies. Our results suggest that platelets and obstruction contributed primarily to the opposite relationships, which might provide new insight into the possible pathophysiology of platelet–tumor interactions generated in the OCRC environment. [ABSTRACT FROM AUTHOR]

Purpose: The prognostic significance of the mean corpuscular volume (MCV) and red cell distribution width (RDW) in patients with malignancy have not been intensely investigated and are largely overlooked. We, therefore, investigated the clinical significance of MCV and RDW in non-metastatic obstructive colorectal cancer (OCRC) patients with a self-expandable metallic stent inserted as a bridge to curative surgery. Methods: Eighty-five pathological stage II and III OCRC patients were retrospectively evaluated. The associations of the preoperative MCV and RDW values with short- and long-term outcomes were examined. Results: There were 50 males and 35 females, and the median age was 71 years old. The median interval between stenting and surgery was 17 days, and the median postoperative hospital stay was 16 days. Fifty-six patients were in the MCV ≥ 87 group, and 47 were in the RDW ≥ 13.8 group. Multivariate analyses revealed the MCV ≥ 87 status to be independently associated with a poor relapse-free survival (hazard ratio [HR] = 4.70, 95% confidence interval [CI] 1.52–14.58, P = 0.007). The RDW ≥ 13.8% was an independent predictor of postoperative infectious complications (HR = 7.28, 95% CI 1.24–42.70, P = 0.028). Conclusion: The MCV and RDW are simple but strong predictors of postoperative outcomes in OCRC patients. [ABSTRACT FROM AUTHOR]

Purpose: Intestinal decompression using self-expandable metallic colonic stents (SEMSs) as a bridge to surgery is now considered an attractive alternative to emergency surgery. However, data regarding the optimal timing of surgery after stenting are limited. Methods: We investigated the impact of the interval between stenting and surgery on short- and long-term outcomes in 92 obstructive colorectal cancer (OCRC) patients who had a SEMS inserted and subsequently received curative surgery. Results: The median age of the patients was 70.5 years, and the median interval between SEMS insertion and the surgery was 17 (range 5–47) days. There were 35 postoperative complications, including seven major postoperative complications. An interval of more than 16 days was an independent predictor of a poor relapse-free survival (hazard ratio [HR] = 3.12, 95% confidence interval [CI] 1.24–7.81, p = 0.015). An interval of more than 35 days was independently associated with major postoperative complications (HR = 16.6, 95% CI 2.21–125, p = 0.006). Conclusion: A longer interval between stenting and surgery significantly compromised the short- and long-term outcomes. Surgery within 16 days after stenting might help maximize the benefit of SEMS without interfering with short- and long-term outcomes. [ABSTRACT FROM AUTHOR]

Valganciclovir (VGCV) has been shown to improve sensorineural hearing loss (SNHL) and neurological outcomes in patients with neonatal symptomatic congenital cytomegalovirus (cCMV) infection. However, reports on the pharmacokinetics, efficacy and safety of oral VGCV are limited. The aim of this study is to evaluate the pharmacokinetics of VGCV for use in the treatment of cCMV. This was a single-center, retrospective observational study conducted at Saitama Children's Medical Center in Japan between 2012 and 2017. CMV DNA copy number, maximum plasma VGCV concentration (Cmax), and adverse events (ADEs) during treatment were evaluated. A total of 26 patients with cCMV who received VGCV were included in this study. The median age at VGCV initiation was 9.5 months (range 0–46). Twenty-one patients (81%) had SNHL at baseline. Of these, five patients (19%) presented with improved SNHL, and none experienced worsened SNHL during treatment. The mean VGCV Cmax was 3.5 μg/mL (range 2–5.3), with no significant variation among individual values, and the values were maintained during treatment. Furthermore, there were no correlations between the Cmax values and age, sex, SNHL improvement or ADEs. Neutropenia (<1000/mm3) was observed in six patients (23%); however, no serious ADEs occurred. VGCV prevented the progression of SNHL without serious ADEs due to its stable pharmacokinetics. This study provides safety and tolerability of VGCV for the treatment of cCMV patients. [ABSTRACT FROM AUTHOR]

Purpose: The Controlling Nutritional Status (CONUT) Score, originally developed as a nutritional screening tool, is a cumulative score calculated from the serum albumin level, total cholesterol level, and total lymphocyte count. Previous studies have demonstrated that the score has significant prognostic value in various malignancies. We investigated the relationship between the CONUT score and long-term survival in obstructive colorectal cancer (OCRC) patients who underwent self-expandable metallic colonic stent placement and subsequently received curative surgery. Methods: We retrospectively analyzed 57 pathological stage II and III OCRC patients between 2013 and 2019. The associations between the preoperative CONUT score and clinicopathological factors and patient survival were evaluated. Results: A receiver operating characteristic curve analysis revealed that the optimal cut-off value for the CONUT score was 7. A CONUT score of ≥ 7 was significantly associated with elevated CA19-9 level (p = 0.03). Multivariate analyses revealed that a CONUT score of ≥ 7 was independently associated with cancer-specific survival (hazard ratio [HR] = 10.2, 95% confidence interval [CI] 1.2–85.9, p = 0.03) and disease-free survival (HR = 7.1, 95% CI 2.3–21.7, p = 0.0006). Conclusion: The results demonstrated that the CONUT score was a potent prognostic indicator. Evaluating the CONUT score might result in more precise patient assessment and tailored treatment. [ABSTRACT FROM AUTHOR]

Background: Oxaliplatin, one of the key cytotoxic drugs for colorectal cancer, frequently causes peripheral neuropathy which leads to dose modification and decreased patients' quality of life. However, prophylactic or therapeutic measures have not yet been established. Orally administered amino acids, cystine and theanine, promoted the synthesis of glutathione which was one of the potential candidates for preventing the neuropathy. The aim of this study was to determine whether daily oral administration of cystine and theanine attenuated oxaliplatin-induced peripheral neuropathy (OXLIPN). Methods: Twenty-eight colorectal cancer patients who received infusional 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) therapy were randomly and evenly assigned to the cystine and theanine group and the control group. OXLIPN was assessed up to the sixth course using original 7-item questionnaire as well as Common Terminology Criteria for Adverse Events (CTCAE) grading scale. Results: Neuropathy scores according to our original questionnaire were significantly smaller in the cystine and theanine group at the fourth (p = 0.026), fifth (p = 0.029), and sixth course (p = 0.038). Furthermore, significant differences were also observed in CTCAE neuropathy grades at the fourth (p = 0.037) and the sixth course (p = 0.017). There was one patient in each group who required dose reduction due to OXLIPN. Except for neurotoxicity, no significant differences were noted in the incidence of adverse events, and the total amount of administered oxaliplatin. Conclusion: The results demonstrated the daily oral administration of cystine and theanine attenuated OXLIPN. [ABSTRACT FROM AUTHOR]

Purpose: Inflammation-based markers predict long-term outcomes of various malignancies. We investigated the relationship between these markers and the long-term survival in obstructive colorectal cancer (OCRC) patients with self-expandable metallic colonic stents (SEMSs) who subsequently received curative surgery. Methods: We retrospectively analyzed 72 consecutive pathological stage II and III OCRC patients between 2013 and 2019. The prognostic significance of the prognostic nutritional index (PNI), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) was evaluated. Results: The overall survival (OS), cancer-specific survival, and disease-free survival (DFS) were significantly shorter in the PNI < 35 group than in the PNI ≥ 35 group (p = 0.006, p < 0.001, and p = 0.003, respectively), and multivariate analyses revealed the PNI to be the only inflammation-based marker independently associated with the survival. A PNI < 35 was significantly associated with an elevated CA 19–9 level (p = 0.04) and longer postoperative hospital stay (p = 0.03). Adjuvant chemotherapy was also significantly associated with the OS (p = 0.040) and DFS (p = 0.011) in multivariate analyses. Conclusion: The results showed that the PNI was a potent prognostic indicator. For OCRC patients, both systemic inflammation and the nutrition status seem to be important for predicting the prognosis, and administering adjuvant chemotherapy was very important. [ABSTRACT FROM AUTHOR]

Background: Predicting tolerability and treatment-related risks associated with azacitidine (AZA) in patients with myelodysplastic syndromes (MDS) before the initiation of therapy is required for appropriate treatment. Thus, in this study, the nutritional status of patients with MDS prior to AZA treatment was evaluated using the geriatric nutritional risk index (GNRI). Tolerability and overall survival (OS) after AZA initiation were also investigated. Methods: This was a single-center retrospective observational study. A total of 59 patients with MDS treated with AZA were assessed using GNRI, and a comparison of undernourished (GNRI <92, n = 27) and non-undernourished (GNRI ≥92, n = 32) patients was performed. Results: The undernourished group had a significant reduction in the number of patients that successfully completed 4 cycles of AZA treatment compared with the non-undernourished group (undernourished group, 11/27 patients, 40.7% vs. non-undernourished group, 24/32 patients, 75.0%; p = 0.009). Factors associated with the difference included karyotype and GNRI. There was also a significant increase in the rate of infectious complications in the undernourished group compared with the non-undernourished group (undernourished group, 33/60 cycles, 55.0% vs. non-undernourished group, 31/92 cycles, 33.7%; p = 0.012). Lastly, a significant reduction in OS was observed in the undernourished group compared with the non-undernourished group (undernourished group, 11.5 months; 95% CI, 5.2–16.7 vs. non-undernourished group, 21.9 months; 95% CI, 13.8–24.0; p = 0.026). Factors associated with OS included both the revised International Prognostic Scoring System (IPSS-R) and GNRI. Conclusions: These results indicate that predicting treatment completion and adverse events in patients with MDS prior to AZA treatment is important. This study suggests GNRI may be a valuable nutritional assessment tool for determining tolerability and OS of AZA treatment. [ABSTRACT FROM AUTHOR]

Purpose: Inflammation-based markers predict the long-term outcomes of various malignancies. We investigated the relationship between the modified Glasgow prognostic score (mGPS) and the long-term outcomes of obstructive colorectal cancer in patients who underwent self-expandable metallic colonic stent placement and subsequently received curative surgery. Methods: We retrospectively analyzed 63 consecutive patients with pathological stage II and III obstructive colorectal cancer from 2013 to 2018. The mGPS was calculated before stenting and surgery, and the difference of the scores was defined as the d-mGPS. Results: All d-mGPS = 2 patients were > 70 years of age (p = 0.01). Postoperative complications were more common in the preoperative mGPS = 2 group (p = 0.02). The postoperative hospital stay was significantly longer in the mGPS = 2 group (p = 0.007). Multivariate analyses revealed that d-mGPS was an independent prognostic factor for overall survival (OS) (hazard ratio [HR] = 9.18, p = 0.004) and cancer-specific survival (HR = 9.98, p = 0.01). Preoperative mGPS = 2 was significantly associated with poor OS (HR = 5.53, p = 0.04). Conclusion: The results indicated that mGPS might serve as a valuable indicator of the immunonutritional status of preoperative patients, and a preoperative change of the status might affect the long-term outcomes of patients with obstructive colorectal cancer. [ABSTRACT FROM AUTHOR]

Soon after the 2011 Tohoku-oki event, approximately 1300 tsunami deposit thickness data were collected spatially by the governors to cover the entire tsunami affected area (Sendai Plain) along the Sendai Bay coastline. This dataset, along with high-resolution and high-precision data of flow depth and pre-tsunami and post-tsunami elevation, enables us first to conduct a direct comparison of the sedimentation and erosion volumes as well as the tsunami hydrodynamic features (e.g., flow depth) and sediment thickness. The total balance of sedimentation and erosion volumes revealed that the volume of tsunami-deposited sediments can be explained roughly using the erosion volumes at the beach and sand dunes for sandy deposits and at rice paddy fields for muddy deposits. Both the flow depth and sediment thickness showed positive correlations with the distance from the shoreline while sediment thickness is no correlation to the elevation except in the zone closest to the shoreline where erosion is present. In addition, a statistical relation was found between the flow depth and sediment thickness. In fact, the frequency distribution of sediment concentration, defined here as the sediment thickness divided by the maximum flow depth at each survey site, fits well with the logarithmic normal distribution with geometric average of about 2%. This fit indicates that the tsunami deposits on the Sendai Plain can be explained generally if we simply assume that the saturated level of the sediment concentration in the flow is limited to about 2% on average, irrespective of the grain size. Such a simple explanation might be applicable only for the tsunami deposits on the Sendai Plain because the topography is remarkably flat and low. Therefore, the tsunami inundation process is relatively simple. Nevertheless, a possible relation between tsunami flow depth and sediment thickness suggested here would be very useful to consider the ideal sedimentary process of the tsunami deposits and to improve forward and inverse modelings. [ABSTRACT FROM AUTHOR]

The interaction between tsunami hydrodynamics and sediment behavior results in a complex depositional process for onshore tsunami deposits. Furthermore, the formation of modern tsunami deposits can be affected by artificial structures, which can make the depositional processes difficult to understand. In the present study, we focus on artificial structures to reveal the relationship between sedimentary structures and hydrodynamics of the 2011 Tohoku-oki tsunami. Field observations indicated that a coastal dike and three shore-parallel roadways significantly affected the source, thickness, and sedimentary structures of the tsunami deposits. The sandy tsunami deposits were mainly sourced from the backshore, which was severely eroded at the landward side of the dike by tsunami overflow. The thickness of the tsunami deposits increased seaward of roadways, while the deposit became thinner landward of roadways. A one-dimensional numerical simulation indicated a local decrease in the flow velocity at the seaward side of roadways, which elucidated the increase in the deposit thickness. Most tsunami deposits are characterized by normal graing, inverse grading, and ungraded units. Inverse grading was observed 0.05 km from the shoreline and at the seaward side of the roadways, except at the most landward roadway. Changes in the grain-size distribution of the deposits and variations in the simulated flow velocity across the roadways suggested that the inverse grading was formed because of waxing and depletive flow conditions with high concentrations of suspended sediments. Our study elucidated the key role that artificial structures play in the formation of tsunami deposits and the resultant sedimentary structures, in developed coastal areas. Artificial structures, which have a somewhat extreme topography compared to the natural geomorphology, also contributed to demonstrate the concept of the acceleration matrix. This is because of the remarkable change in the steadiness and uniformity of the tsunami flow and the resultant sedimentary structures. [ABSTRACT FROM AUTHOR]