12 results on '"Stanford, Miles"'
Search Results
2. An Algorithm for the Diagnosis of Behçet Disease Uveitis in Adults.
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Tugal-Tutkun, Ilknur, Onal, Sumru, Stanford, Miles, Akman, Mehmet, Twisk, Jos W.R., Boers, Maarten, Oray, Merih, Özdal, P., Kadayifcilar, Sibel, Amer, Radgonde, Rathinam, Sivakumar R., Vedhanayaki, Rajesh, Khairallah, Moncef, Akova, Yonca, Yalcindag, F., Kardes, Esra, Basarir, Berna, Altan, Çigdem, Özyazgan, Yilmaz, and Gül, Ahmet
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IRIDOCYCLITIS , *BEHCET'S disease , *CART algorithms , *UVEITIS , *DIAGNOSIS , *ADULTS - Abstract
Purpose: To develop an algorithm for the diagnosis of Behçet's disease (BD) uveitis based on ocular findings. Methods: Following an initial survey among uveitis experts, we collected multi-center retrospective data on 211 patients with BD uveitis and 207 patients with other uveitides, and identified ocular findings with a high diagnostic odds ratio (DOR). Subsequently, we collected multi-center prospective data on 127 patients with BD uveitis and 322 controls and developed a diagnostic algorithm using Classification and Regression Tree (CART) analysis and expert opinion. Results: We identified 10 items with DOR >5. The items that provided the highest accuracy in CART analysis included superficial retinal infiltrate, signs of occlusive retinal vasculitis, and diffuse retinal capillary leakage as well as the absence of granulomatous anterior uveitis or choroiditis in patients with vitritis. Conclusion: This study provides a diagnostic tree for BD uveitis that needs to be validated in future studies. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. Endogenous Meningococcal Endophthalmitis with Isolated Joint Involvement in Immunocompetent Adults.
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Shah, Vishal, Garg, Anurag, and Stanford, Miles
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MENINGOCOCCAL infections , *NEISSERIA meningitidis , *POLYMERASE chain reaction , *ANTIBIOTICS , *JOINT diseases - Abstract
Purpose: We report two cases of endogenous meningococcal endophthalmitis in immunocompetent adults presenting with unilateral ocular disease and joint involvement.Methods: A retrospective review of two patients with endogenous endophthalmitis due to Neisseria meningitidis with associated arthropathy was conducted. The clinical presentation, investigations, treatment, and outcomes are presented.Results: Vitreous sampling confirmed Neisseria meningitidis via polymerase chain reaction (PCR) in both cases. PCR was positive from the knee aspirate of our second case. Both patients received topical steroids and topical, intravitreal and intravenous antibiotics. Despite this, visual outcomes were poor.Conclusions: This atypical combination of endogenous meningococcal endophthalmitis associated with meningococcal joint involvement could represent a novel pattern for the presentation of metastatic meningococcal endophthalmitis not previously described. We suggest joint aspirate PCR could be a useful adjunctive test to identify potential causative organisms in such cases where there is concurrent joint involvement in the absence of systemic features. [ABSTRACT FROM AUTHOR]- Published
- 2018
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4. The Pathogenesis of Raised Intraocular Pressure in Uveitis.
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Baneke, Alexander Jan, Lim, K. Sheng, and Stanford, Miles
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INTRAOCULAR pressure , *GLAUCOMA , *UVEITIS , *LITERATURE reviews , *OCULAR hypertension , *TRABECULAR meshwork (Eye) , *PATIENTS , *THERAPEUTICS , *DISEASE risk factors - Abstract
Aim: To analyze current understanding of the factors that contribute to raised intraocular pressure (IOP) in patients with uveitis. Methods: A pubmed literature review was carried out using words including “uveitic glaucoma”, “IOP AND uveitis”, “ocular hypertension AND uveitis”, “inflammation AND glaucoma”, “aqueous dynamics” AND “glaucoma/uveitis”. Results: Of the two studies looking at the aqueous dynamics in experimentally induced uveitis, both found aqueous flow decreased acutely, and one found that uveoscleral outflow increased. This is likely to reflect the types of uveitis that present acutely with hypotony. A study examining patients with Fuch’s heterochromic cyclitis found no difference in aqueous flow or uveoscleral outflow. No studies have examined aqueous dynamics in types of uveitis that present with acutely raised IOP. Levels of prostaglandins rise in acute uveitis, which has been shown to increase uveoscleral and trabecular outflow, without affecting aqueous flow. Studies have demonstrated that raised levels of trabecular protein reduce trabecular outflow. Steroid treatment, inflammatory cells, free radicals and enzymes are also likely to contribute to the development of raised pressure. When considering the impact of the pathogenesis of raised pressure in uveitis on its treatment, prostaglandins may provide good intraocular pressure control, but there are concerns regarding their theoretical ability to worsen the inflammatory response in uveitis. Studies have not conclusively proven this to be the case. Surgical success rates vary, but trabeculectomy plus an antimetabolite, deep sclerectomy plus an antimetabolite, and Ahmed valve surgery have been used. Conclusions: Uveitic glaucoma is caused by a number of different diseases, some of which present with acute hypotony, others with acutely raised IOP, and others which demonstrate an increase in IOP over time. Further studies should be carried out to examine the differing pathogenesis in these types of diseases, and to establish the best treatment options. [ABSTRACT FROM AUTHOR]
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- 2016
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5. Aspergillus fumigatus Endophthalmitis with Necrotizing Scleritis following Pars Plana Vitrectomy.
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Gruener, Anna M., Allen, Felicity, Stanford, Miles R., and Graham, Elizabeth M.
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ASPERGILLUS fumigatus , *NECROTIZING pancreatitis , *PARS plana , *VITRECTOMY , *STEROIDS , *ETIOLOGY of diseases - Abstract
We present a case of Aspergillus fumigatus endophthalmitis complicated by necrotizing scleritis in a 68-year-old man with diet-controlled diabetes, after retinal detachment repair. He was initially treated with systemic steroids for surgically induced necrotizing scleritis following routine pars plana vitrectomy. An additional diagnosis of endophthalmitis was made when the patient developed a hypopyon. Repeat vitreous culture isolated Aspergillus fumigatus. Symptoms improved following antifungal treatment leaving the patient with scleromalacia and an advanced postoperative cataract. Fungal scleritis and endophthalmitis are rare complications of intraocular surgery with sight-threatening consequences, and, as this case demonstrates, may even occur concomitantly. The overlapping features of both conditions can make differentiating one from the other difficult. A fungal aetiology should be considered in cases of postoperative scleritis and endophthalmitis that are protracted and refractory to standard therapy. Even in cases of early diagnosis and treatment, visual outcomes in Aspergillus endophthalmitis and scleritis are variable and often disappointing, not infrequently necessitating enucleation of a painful blind eye. [ABSTRACT FROM AUTHOR]
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- 2016
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6. KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behçet Disease.
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Petrushkin, Harry, Norman, Paul J., Lougee, Emma, Parham, Peter, Wallace, Graham R., Stanford, Miles R., and Fortune, Farida
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ODDS ratio , *CHRONIC diseases , *CONFIDENCE intervals , *DISEASES - Abstract
Behçet disease is a chronic, relapsing-remitting autoinflammatory syndrome with a strong HLA-B*51 association. In this paper, we describe a human cohort of 267 individuals with Behçet disease and 445 matched controls from a tertiary referral center in the U.K. HLA-B*51 was confirmed as a genetic risk factor in this group (p = 0.0006, Bonferroni-Dunn correction for multiple testing [Pc] = 0.0192, odds ratio [OR] 1.92, 95% confidence interval [CI] 1.33-2.76). KIR3DL1/S1 allele-level analysis indicated that low-expressing KIR3DL1/S1 alleles in combination with KIR3DS1 increased the risk of developing Behçet disease (KIR3DL1LOW/KIR3DS1: p = 0.0004, Pc = 0.0040, OR 2.47, 95% CI 1.43-4.25), whereas high-expressing KIR3DL1/S1 alleles in combination with a null-expressing KIR3DL1 reduced the risk of disease (KIR3DL1HIGH/KIR3DL1NULL: p = 0.0035, Pc = 0.0350, OR 0.53, 95% CI 0.33-0.87). Behçet disease can manifest as a purely mucocutaneous disease or can involve other organ systems such as the eyes. In the U.K. cohort studied in this study, KIR3DL1LOW/KIR3DS1 increased the risk of ophthalmic disease (p = 1.2 × 10-5, OR 3.92, 95% CI 2.06-7.47), whereas KIR3DL1HIGH/KIR3DL1NULL reduced the risk of having purely mucocutaneous disease (p = 0.0048, OR 0.45, 95% CI 0.25-0.81). To our knowledge, this is the first analysis of KIR3DL1/S1 allelic variation in Behçet disease and may provide insight into the pathogenic role of HLA-B*51 and its interaction with KIR3DL1/S1. [ABSTRACT FROM AUTHOR]
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- 2019
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7. Homonymous Sectoranopia: Asymptomatic Presentation of a Lateral Geniculate Nucleus Lesion.
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Pasu, Saruban, Ridha, Basil H., Wagh, Vijay, Jindahra, Panitha, Siddiqui, Ata, Plant, Gordon, and Stanford, Miles
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BRAIN cancer , *LATERAL geniculate body , *PATHOLOGY , *MEDICAL sciences , *BRAIN metastasis - Abstract
This is a rare presentation of brain tumour in the region of the lateral geniculate nucleus (LGN) presenting as a homonymous horizontal sectoranopia (HHS). The case highlights that subtle field defects can be asymptomatic and only detected by formal perimetry. Although homonymous sectoranopia is a rare form of visual field defect, it should be recognised as a potential manifestation of potentially significant intracranial pathology. [ABSTRACT FROM AUTHOR]
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- 2015
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8. Genome-Wide Association Study in an Admixed Case Series Reveals IL12A as a New Candidate in Behçet Disease.
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Kappen, Jasper H., Medina-Gomez, Carolina, Hagen, P. Martin van, Stolk, Lisette, Estrada, Karol, Rivadeneira, Fernando, Uitterlinden, Andre G., Stanford, Miles R., Ben-Chetrit, Eldat, Wallace, Graham R., Soylu, Merih, and Laar, Jan A.M. van
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BEHCET'S disease , *ETIOLOGY of diseases , *DISEASE prevalence , *COHORT analysis , *REGRESSION analysis - Abstract
Introduction: The etiology of Behçet’s disease (BD) is unknown, but widely considered an excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent genome-wide association studies (GWAS) have shown limited number of novel loci-associations. The rarity and unequal distribution of the disease prevalence amongst different ethnic backgrounds have hampered the use of GWAS in cohorts of mixed ethnicity and sufficient sample size. However, novel statistical approaches have now enabled GWAS in admixed cohorts. Methods: We ran a GWAS on 336 BD cases and 5,843 controls. The cases consisted of Western Europeans, Middle Eastern and Turkish individuals. Participants from the Generation R study, a multiethnic birth cohort in Rotterdam, The Netherlands were used as controls. All samples were genotyped and data was combined. Linear regression models were corrected for population stratification using Genomic Principal Components and Linear Mixed Modelling. Meta-analysis was performed on selected results previously published. Results: We identified SNPs associated at genome-wide significant level mapping to the 6p21.33 (HLA) region. In addition to this known signal two potential novel associations on chromosomes 6 and 18 were identified, yet with low minor allele frequencies. Extended meta-analysis reveal a GWS association with the IL12A variant rs17810546 on chromosome 3. Discussion: We demonstrate that new statistical techniques enable GWAS analyses in a limited sized cohort of mixed ethnicity. After implementation, we confirmed the central role of the HLA region in the disease and identified new regions of interest. Moreover, we validated the association of a variant in the IL2A gene by meta-analysis with previous work. These findings enhance our knowledge of genetic associations and BD, and provide further justification for pursuing collective initiatives in genetic studies given the low prevalence of this and other rare diseases. [ABSTRACT FROM AUTHOR]
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- 2015
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9. Spectral Domain Optical Coherence Tomography Findings in a Case Series of Patients with Bilateral Diffuse Uveal Melanocytic Proliferation.
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Shalchi, Zaid, Shunmugam, Manoharan, Mahroo, Omar A., McDonald, Robert J., Dogramaci, Mahmut, Laidlaw, D. Alistair H., Stanford, Miles, and Mohamed, Moin
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OPTICAL coherence tomography , *PARANEOPLASTIC syndromes - Abstract
A letter to the editor is presented discussing a mini case series of spectral domain optical coherence tomography (OCT) findings in bilateral diffuse uveal melanocytic proliferation (BDUMP), a rare paraneoplastic disorder.
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- 2014
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10. Chronic postoperative fungal endophthalmitis caused by Penicillium citrinum after cataract surgery.
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Garg, Anurag, Stuart, Alastair, Fajgenbaum, Mark, Laidlaw, David Alistair, and Stanford, Miles
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CATARACT surgery , *SURGICAL complications , *PENICILLIUM , *HYPOPYON , *POLYMERASE chain reaction - Abstract
An 85-year-old man developed chronic postoperative endophthalmitis after complicated cataract surgery. Visual acuity in the affected eye was hand movements. Slitlamp biomicroscopy showed a hypopyon, superonasal iris nodule, and marked vitritis. An anterior chamber washout, iris biopsy, and intravitreal amphotericin injection were performed. Panfungal polymerase chain reaction of anterior chamber and vitreous samples were positive for Penicillium citrinum . The iris biopsy showed hyphae on Grocott staining. Despite treatment, the patient's acuity deteriorated to light perception and he developed severe intractable pain requiring evisceration. Histological analysis showed diffuse infiltration of hyphae. Penicillium species are fungal organisms that are ubiquitous in the environment and can cause chronic endophthalmitis. They are commonly dismissed as culture contaminants. True infection is confirmed by histological demonstration of fungal invasion. Diagnosis can be aided by iris biopsy if iris nodules are present. Polymerase chain reaction testing was beneficial in identifying the causative organism and should be considered early in endophthalmitis cases. Despite intravitreal and systemic antifungal treatment, the visual prognosis for this condition is variable. Financial Disclosure None of the authors has a financial or proprietary interest in any material or method mentioned. [ABSTRACT FROM AUTHOR]
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- 2016
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11. Comparison of peak times of photopic flicker electroretinogram responses recorded using conventional and portable systems in Birdshot chorioretinopathy.
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Pekacka, Aleksandra, Hobby, Angharad, Chow, Isabelle, Indusegaran, Mathura, Hammond, Christopher, Stanford, Miles, and Mahroo, Omar
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UVEITIS , *SCHOOL children , *STANDARD deviations , *ELECTRODES - Abstract
Purpose: Assessing disease activity in Birdshot uveitis can be challenging. The peak time of the 30 Hz flicker photopic electroretinogram (ERG) was shown to be sensitive for detecting retinal dysfunction. ERG testing is not readily available in many eye units. We investigated use of a portable device to obtain recordings in the clinic setting and compared these with conventional recordings. Methods: Patients underwent testing with the portable device (RETeval, LKC Technologies) and conventional equipment (Espion ColorDome, Diagnosys). For portable recordings pupils were undilated and skin electrodes used; for conventional recordings a conductive fibre electrode was used with mydriasis. Flicker ERG peak times were recorded and were deemed abnormal if they exceeded the 95th centile from a healthy cohort (>190 healthy volunteers). Results: 18 patients with Birdshot uveitis underwent recordings. Recordings with the portable device took c. 3 min and were well‐tolerated. Mean (SD) age was 56.3 (12.8) years. For portable recordings, mean (SD) peak times were 30.1 (3.7) and 30.2 (3.9) ms for right and left eyes respectively. For conventional recordings mean (SD) peak times were 31.4 (3.9) and 31.8 (4.0) ms respectively. Peak times were significantly shorter with the portable device (p = 0.026 and 0.002 for right and left eyes). Correlation between devices was high (0.83 and 0.89 for right and left eyes) and highly significant (p < 0.0001). Strength of agreement between the two methods was good (kappa statistic 0.64; 95% CI, 0.36‐0.92). Conclusions: Correlation between the portable and conventional ERG recordings was high with a good level of agreement. Recordings were rapid and well‐tolerated. There were significant differences in peak times between the two methods highlighting the importance of normative data specific to each device. [ABSTRACT FROM AUTHOR]
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- 2019
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12. High Prevalence of Untreated Depression in Patients Accessing Low-Vision Services.
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Nollett, Claire L., Bray, Nathan, Bunce, Catey, Casten, Robin J., Edwards, Rhiannon T., Hegel, Mark T., Janikoun, Sarah, Jumbe, Sandra E., Ryan, Barbara, Shearn, Julia, Smith, Daniel J., Stanford, Miles, Xing, Wen, and Margrain, Tom H.
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DISEASE prevalence , *MENTAL depression , *LOW vision , *PSYCHOLOGICAL well-being , *MEDICAL rehabilitation - Published
- 2016
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