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The mathematical analysis on the behavior of the entropy for viscous, compressible, and heat conducting magnetohydrodynamic flows near the vacuum region is a challenging problem as the governing equation for entropy is highly degenerate and singular in the vacuum region. In our previous work [38] , we investigate the global existence of strong solutions to the three-dimensional (3D) compressible heat-conducting magnetohydrodynamic equations with vacuum at infinity. However, it is unknown whether the entropy remains its boundedness or not? Thus, the main novelty of this paper is to give a positive response to this problem. In fact, we show that the uniform boundedness of the entropy and the L 2 regularities of the velocity and temperature can be propagated provided that the initial density decays suitably slow at infinity. Modified De Giorgi type iteration techniques and useful singularly weighted estimates are developed to deduce the lower and upper bounds on the entropy. [ABSTRACT FROM AUTHOR]