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Current global COVID-19 booster scheduling strategies mainly focus on vaccinating high-risk populations at predetermined intervals. However, these strategies overlook key data: the direct insights into individual immunity levels from active serological testing and the indirect information available either through sample-based sero-surveillance, or vital demographic, location, and epidemiological factors. Our research, employing an age-, risk-, and region-structured mathematical model of disease transmission—based on COVID-19 incidence and vaccination data from Israel between 15 May 2020 and 25 October 2021—reveals that a more comprehensive strategy integrating these elements can significantly reduce COVID-19 hospitalizations without increasing existing booster coverage. Notably, the effective use of indirect information alone can considerably decrease COVID-19 cases and hospitalizations, without the need for additional vaccine doses. This approach may also be applicable in optimizing vaccination strategies for other infectious diseases, including influenza. [ABSTRACT FROM AUTHOR]

Current global COVID-19 booster scheduling strategies mainly focus on vaccinating high-risk populations at predetermined intervals. However, these strategies overlook key data: the direct insights into individual immunity levels from active serological testing and the indirect information available either through sample-based sero-surveillance, or vital demographic, location, and epidemiological factors. Our research, employing an age-, risk-, and region-structured mathematical model of disease transmission—based on COVID-19 incidence and vaccination data from Israel between 15 May 2020 and 25 October 2021—reveals that a more comprehensive strategy integrating these elements can significantly reduce COVID-19 hospitalizations without increasing existing booster coverage. Notably, the effective use of indirect information alone can considerably decrease COVID-19 cases and hospitalizations, without the need for additional vaccine doses. This approach may also be applicable in optimizing vaccination strategies for other infectious diseases, including influenza. [ABSTRACT FROM AUTHOR]

Malicious websites pose a challenging cybersecurity threat. Traditional tools for detecting malicious websites rely heavily on industry-specific domain knowledge, are maintained by large-scale research operations, and result in a never-ending attacker–defender dynamic. Malicious websites need to balance two opposing requirements to successfully function: escaping malware detection tools while attracting visitors. This fundamental conflict can be leveraged to create a robust and sustainable detection approach based on the extraction, analysis, and learning of design attributes for malicious website identification. In this paper, we propose a next-generation algorithm for extended design attribute learning that learns and analyzes web page structures, content, appearances, and reputation to detect malicious websites. Results from a large-scale experiment that was conducted on more than 35,000 websites suggest that the proposed algorithm effectively detects more than 83% of all malicious websites while maintaining a low false-positive rate of 2%. In addition, the proposed method can incorporate user feedback and flag new suspicious websites and thus can be effective against zero-day attacks. [ABSTRACT FROM AUTHOR]