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The optimization problems are becoming more complicated, requiring new and efficient optimization techniques to solve them. Many bio-inspired meta-heuristic algorithms have emerged in the last decade to solve these complex problems as most of these algorithms may be trapped into local optima and could not effectively solve all types of optimization problems. Hence, researchers are still trying to develop new and better optimization algorithms. This paper introduces a novel biologically-based optimization algorithm called circulatory system-based optimization (CSBO). CSBO is modeled based on the function of the body's blood vessels with two distinctive circuits, i.e. pulmonary and systemic circuits. The proposed CSBO algorithm is tested on a wide variety of complex functions of the real world and validated with the standard meta-heuristic algorithms. The results indicate that the CSBO algorithm successfully achieves the optimal solutions and avoids local optima. Note that the source code of the CSBO algorithm is publicly available at . [ABSTRACT FROM AUTHOR]