1. Charcot‐Leyden crystals in tissues.
- Author
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Sasaki, Tomoko, Suzaki, Isao, and Ueki, Shigeharu
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CRYSTALS , *TISSUES , *NASAL polyps , *CELL death , *CELL nuclei - Abstract
Keywords: ENT; eosinophil; immunology; rhinosinusitis EN ENT eosinophil immunology rhinosinusitis 1 2 2 07/26/23 20230701 NES 230701 To the Editor, We read with interest the paper by Chen et al. entitled "Predictive significance of Charcot-Leyden crystal (CLC) structures for nasal polyp recurrence".[1] CLCs are formed when galectin-10 crystallizes intracellularly or extracellularly through eosinophil ETosis, an active cell death process involving the disruption of the cell nucleus and plasma membrane to release web-like chromatin structures.[[2]] Intact eosinophil granules are also released during this process, typically characterized by the presence of cell-free eosinophil granules (Cfegs).[2] In the H&E-stained specimens shown by Chen et al., most eosinophils in the nasal polyp tissues have barely retained their morphology, and both cell disruption with web-like nuclear contents and Cfegs are clearly visible. Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. [Extracted from the article]
- Published
- 2023
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