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Keywords: ENT; eosinophil; immunology; rhinosinusitis EN ENT eosinophil immunology rhinosinusitis 1 2 2 07/26/23 20230701 NES 230701 To the Editor, We read with interest the paper by Chen et al. entitled "Predictive significance of Charcot-Leyden crystal (CLC) structures for nasal polyp recurrence".[1] CLCs are formed when galectin-10 crystallizes intracellularly or extracellularly through eosinophil ETosis, an active cell death process involving the disruption of the cell nucleus and plasma membrane to release web-like chromatin structures.[[2]] Intact eosinophil granules are also released during this process, typically characterized by the presence of cell-free eosinophil granules (Cfegs).[2] In the H&E-stained specimens shown by Chen et al., most eosinophils in the nasal polyp tissues have barely retained their morphology, and both cell disruption with web-like nuclear contents and Cfegs are clearly visible. Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. [Extracted from the article]

For over 30 years, Bob has studied basophils and mast cells and published many important and impactful papers describing the regulation of their signaling, activation, and products especially in human allergic diseases. Allergic disease, basophil, sinusitis, eosinophils, mast cells, ENT (rhinitis, nasal polyps...) Bob first became interested in the role of basophils and mast cells, key effector cells in the allergic response. [Extracted from the article]