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With the development of genome-wide association studies, how to gain information from a large scale of data has become an issue of common concern, since traditional methods are not fully developed to solve problems such as identifying loci-to-loci interactions (also known as epistasis). Previous epistatic studies mainly focused on local information with a single outcome (phenotype), while in this paper, we developed a two-stage global search algorithm, Greedy Equivalence Search with Local Modification (GESLM), to implement a global search of directed acyclic graph in order to identify genome-wide epistatic interactions with multiple outcome variables (phenotypes) in a case–control design. GESLM integrates the advantages of score-based methods and constraint-based methods to learn the phenotype-related Bayesian network and is powerful and robust to find the interaction structures that display both genetic associations with phenotypes and gene interactions. We compared GESLM with some common phenotype-related loci detecting methods in simulation studies. The results showed that our method improved the accuracy and efficiency compared with others, especially in an unbalanced case–control study. Besides, its application on the UK Biobank dataset suggested that our algorithm has great performance when handling genome-wide association data with more than one phenotype. [ABSTRACT FROM AUTHOR]

This paper aims to demonstrate how knowledge acquired from occupants' manual window operations can be implemented into BMS automated window operation algorithms. Ten single-occupant offices were selected in a university building in the UK. More than 28,000 hourly data points on indoor and outdoor temperature and open window area (OWA) were analysed from 2015 to 2020. The BMS had adopted nine different automated window operation algorithms during the 5 years. The automated window algorithms could be manually overridden by the office occupants. Automated algorithms were compared against manual window operations. The results showed that the slope and gradient of the regression lines for occupants' manual window operations are smaller than automated operations. OWA of automated window operations increased 20% per 1 °C increase in indoor temperature, however, occupants opened windows 6–8% per 1 °C increase. Occupants react slower to temperature changes than assumed by BMS, which could be considered in BMS automated window operations. • BMS automated window algorithms operate based on indoor temperature in this study. • Automated window operations by BMS impact occupants' manual window operations. • Occupants open windows at higher temperatures on the third floor than first floor. • BMSs need to consider building-related differences and seasonal changes. • A BMS system architecture is proposed to reduce the behaviour gap. [ABSTRACT FROM AUTHOR]