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The issues that social researchers study and policymakers address are partly determined by how they think about the world around them. Their view of the social world often depends on their position within it. What their research reveals and their policies propose are, in part, a reflection of where they choose to look and how they interpret the world they identify. The result can be a myopic view of the social and a distorted explanation of how social relations work. In this paper, we argue the need to widen the aperture of the lens that social researchers and policymakers use to investigate and ameliorate educational disadvantage. In particular, in matters of education equity, beyond measuring opportunities and outcomes of target groups, we argue the need to consider the substantiveness of opportunities as well as the subjective conditions and objective contexts that mediate how people transform their resources into outcomes. Drawing on the work of both Bourdieu and Sen, we propose an expanded evaluative framework that outlines five spaces for assessing educational disadvantage: position and disposition, capital interaction, capability expansion, conversion ability, and conditioned choices. [ABSTRACT FROM AUTHOR]

Oncolytic viruses have emerged as a promising modality in cancer treatment given their high synergy with highly efficient immune checkpoint inhibitors. However, their potency is limited by their rapid in vivo clearance. To overcome this, we coated oncolytic vaccinia viruses (oVV) with erythrocyte-derived membranes (EDMs), hypothesizing that they would not only remain in systemic circulation for longer as erythrocytes would when administered intravenously, but also respond to environmental pH cues due to their membrane surface sialic acid residues. For this, we developed a model based on DLVO theory to show that the acidic moieties on the surface of EDM confers it the ability to respond to pH-based stimuli. We corroborate our modeling results through in vitro cell culture models and show that EDM-coated oVV infects cancer cells faster under acidic conditions akin to the tumor microenvironment. When EDM-coated oVVs were intravenously injected into wild-type mice, they exhibited prolonged circulation at higher concentrations when compared to the unprocessed oVV. Furthermore, when EDM-coated oVV was directly injected into xenografted tumors, we observed that they were suppressed earlier than the tumors that received regular oVV, suggesting that the EDM coating does not hinder oVV infectivity. Overall, we found that EDM was able to serve as a multi-functional encapsulant that allowed the payload to remain in circulation at higher concentrations when administered intravenously while simultaneously exhibiting pH-responsive properties. [ABSTRACT FROM AUTHOR]