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This research constructs a 26 GHz waveguide slot antenna with decent gain. The application of millimeter-wave requires high bandwidth and gain to increase the traffic and users for millimeter-wave and 5G technology. The application of millimeter waves requires a high gain and bandwidth to achieve the requirements of traffic and users increasing for 5G technology and existing millimeter-wave. High-gain and power handling are provided by waveguide slot antennas. Three waveguide structures which are two waveguide antennae and a waveguide horn have been simulated by using CST and fabricated by a 3D printer. The tilt technique has been used with a waveguide to increase the bandwidth and gain of an antenna. A waveguide with broad wall tilt slots has one diction beam while a waveguide with broad and narrow wall tilt slots has two direction beams, each length of the wall enough to distribute six symmetric tilt slots. The gain of 14.3 dB and 1.9 GHz bandwidth are recorded for an antenna with broad wall tilt slots with one beam. While the waveguide with broad and narrow wall tilt slots achieved a gain of 13.9dB and a bandwidth of 1.9 GHz. The proposed antenna is a decent candidate for use with millimeter waves. [ABSTRACT FROM AUTHOR]

TGFBI-related corneal dystrophy (CD) is characterized by the accumulation of insoluble protein deposits in the corneal tissues, eventually leading to progressive corneal opacity. Here we show that ATP-independent amyloid-β chaperone L-PGDS can effectively disaggregate corneal amyloids in surgically excised human cornea of TGFBI-CD patients and release trapped amyloid hallmark proteins. Since the mechanism of amyloid disassembly by ATP-independent chaperones is unknown, we reconstructed atomic models of the amyloids self-assembled from TGFBIp-derived peptides and their complex with L-PGDS using cryo-EM and NMR. We show that L-PGDS specifically recognizes structurally frustrated regions in the amyloids and releases those frustrations. The released free energy increases the chaperone’s binding affinity to amyloids, resulting in local restructuring and breakage of amyloids to protofibrils. Our mechanistic model provides insights into the alternative source of energy utilized by ATP-independent disaggregases and highlights the possibility of using these chaperones as treatment strategies for different types of amyloid-related diseases.ATP-independent amyloid-β chaperone L-PGDS disaggregates corneal amyloids in surgically excised human cornea of TGFBI-related corneal dystrophy patients by recognizing and releasing structurally frustrated regions. [ABSTRACT FROM AUTHOR]