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SUMMARY Distributed generation (DG) systems are small-scale power generation technologies that offer better reliability of supply, reduced transmission, and distribution losses and cost. The benefits of DG greatly depend on their placement and size. Most of the existing analytical methods developed so far are applicable for single DG installation only. Further, in meta-heuristic-based methods, location and sizing problem of DG were dealt separately in which optimal locations are identified with sensitivity-based methods, and optimal sizing is obtained using meta-heuristic algorithms which may lead to incorrect location and suboptimal sizing. In this paper, a novel method that employs harmony search algorithm with differential operator is proposed to install multiple DG units optimally in distribution system with an objective of minimizing active power loss and improving voltage profile. The proposed method is tested on 33-bus and 69-bus radial distribution systems to demonstrate its performance and efficacy. Results show that the proposed method is superior to existing methods in quality of solution. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]